Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury  

作　　者：Andreia Monteiro Susana Monteiro Nuno A.Silva 

机构地区：[1]Life and Health Sciences Research Institute(ICVS),School of Medicine,University of Minho,Braga,Portugal [2]ICVS/3B’s Associate Lab,PT Government Associated Lab,Braga/Guimaraes,Portugal

出　　处：《Neural Regeneration Research》2025年第11期3231-3232,共2页中国神经再生研究（英文版）

基　　金：funded by national funds,through the Foundation for Science and Technology(FCT)-project UIDB/50026/2020,UIDP/50026/2020(to NAS),EXPL/MEDPAT/0931/2021(to SM);Financial support was provided by Prémios Santa Casa Neurociências-Prize Melo e Castro for Spinal Cord Injury Research(MC-18-2021);Wings For Life Spinal Cord Research Foundation(WFL-PT-14/23);"la Caixa"Foundation(HR23-00484)(to NAS);the FCT for the Scientific Employment Stimulus to NAS and SM(CEECIND/04794/2017 and CEECIND/01902/2017)。

摘　　要：Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury site.While the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关 键 词：alterations injury COMPANIES 

分 类 号：R651.2[医药卫生—外科学]