微化工技术在纳米药物递送系统中的应用  

Application of microchemical technology in nano-drug delivery system

作　　者：刘志凯 姚望 陈戴欣 郭乐陶 杨梅[1] 陈光文[1] Zhikai Liu;Wang Yao;Daixin Chen;Letao Guo;Mei Yang;Guangwen Chen(Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China)

机构地区：[1]中国科学院大连化学物理研究所,大连116023

出　　处：《中国科学：化学》2024年第11期2037-2054,共18页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金项目(编号:21991103,22178336,92034303);大连化学物理研究所创新基金(DICP I202216)资助。

摘　　要：纳米药物递送系统利用纳米尺度载体包裹药物,通过结构设计、尺寸调控、表面功能化修饰等策略,克服生物屏障,增强稳定性与靶向性.然而,传统制备技术难以满足纳米药物递送系统粒径与结构可控制备的需求.微化工技术以其高效的热质传递、精准可控的反应条件以及过程可放大性等优势,在纳米药物递送系统制备中展现出巨大潜力.本文综述了微化工技术在纳米药物递送系统制备中的应用,包括微混合技术原理、典型纳米载体形成机制及连续可控制备策略.展望未来,动力学调控的多步微反应逐级组装等新兴策略有望进一步推动纳米载体的精准构筑与临床转化.Nano-drug delivery systems utilize nanoscale carriers to encapsulate drugs,employing strategies,such as structural design,size control,and surface functionalization,to overcome biological barriers and enhance stability and targeting.However,traditional preparation methods often fail to meet the demands for controlled size and structure of nano-drug delivery systems.Microchemical technology,with its advantages of efficient heat and mass transfer,precisely controllable reaction conditions,and scalability,shows great potential in the preparation of nano-drug delivery systems.This review summarizes the application of microchemical technology in the preparation of nano-drug delivery systems,including the principles of micromixing technology,the formation mechanisms of typical nanocarriers,and continuous controllable preparation strategies.In the future,emerging strategies,such as the sequential assembly of nanocarriers through multistep microreactions with kinetic control,are expected to further advance the precise construction and clinical translation of nanocarriers.

关 键 词：微化工 纳米药物递送系统 微混合 聚合物纳米颗粒 脂质纳米颗粒 

分 类 号：TQ460.4[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程] TQ02