巴豆酰化修饰在前列腺增生组织中的表达及其与尿动力学参数的相关性分析  

Analysis of crotonylation protein expression in benign prostatic hyperplasia and its correlation with urodynamics parameters

作　　者：胡婷 袁小娟 方针强 杨振兴 Hu Ting;Yuan Xiaojuan;Fang Zhenqiang;Yang Zhenxing(Department of Urology,Second Affiliated Hospital,Army Medical University,Chongqing 400037,China)

机构地区：[1]陆军军医大学第二附属医院泌尿外科,重庆400037

出　　处：《中华泌尿外科杂志》2024年第11期866-868,共3页Chinese Journal of Urology

基　　金：国家自然科学基金(82270821)。

摘　　要：蛋白翻译后巴豆酰化修饰在良性前列腺增生(BPH)中的表达,以及与临床尿动力学参数的相关性研究缺乏。本研究收集我院176例BPH患者的前列腺组织,进行巴豆酰化泛抗体染色,并分析其与临床参数的相关性。26例(14.77%)BPH组织胞质有高水平巴豆酰化修饰,71例(40.34%)中水平修饰;79例(44.89%)低水平修饰。77例(43.75%)胞核染色阳性,其中12例高水平修饰,18例中水平修饰,47例低水平修饰。胞质高水平修饰组的前列腺体积[(90.15±29.88)ml]显著高于中水平和低水平修饰组[(52.53±28.68)ml和(43.33±19.65)ml]。尿动力学参数中,逼尿肌压和前列腺平台面积在胞质高水平修饰组[(63.2±36.2)cmH_(2)0和(2011.2±518.7)mm·cmH_(2)O]中显著高于中水平[(45.0±25.4)cmH_(2)0和(1319.1±564.4)mm·cmH_(2)0]和低水平修饰组[(37.1±19.5)cmH_(2)0和(1496.4±520.1)mm·cmH_(2)0](均P<0.01)。高水平巴豆酰化修饰与BPH组织增生,以及患者的尿动力学表现相关,可能参与BPH的发生发展。No research considering the expression of protein post-translational crotonylation in benign prostate hyperplasia(BPH),and the correlation between crotonylation and clinical urodynamic testing parameters.176 BPH samples collected in our hospital were stained with crotonylation pan-antibody,and the correlation between staining scores and urodynamic test parameters were analyzed.The results showed that 14.77% of BPH tissues had high levels,40.34% had moderate levels,and 44.89% had low levels of crotonylation modification in cytoplasm.43.75% of BPH tissue cell nuclei were stained positive,of which 12 cases showed high levels,18 cases had medium levels,and 47 cases had low levels of crotonylation modification.The volume of BPH tissue with high-level cytoplasmic crotonylation modified[(90.15±29.88)ml]was significantly higher than that of medium-level[(52.53±28.68)ml]and low-level[(43.33±19.65)ml]tissues(P<0.001).Parameters from urodynamics including detrusor pressure and prostate plateau area were significantly higher in the high-level crotonylation group[(63.21±36.25)cmH_(2)0 and(2011.2±518.7)mm·cmH_(2)0]than those in the medium-[(45.0±25.4)cmH_(2)0 and(1319.1±564.4)mm·cmH_(2)0]and low-level[(37.1±19.5)cmH_(2)0 and(1496.4±520.1)mm·cmH_(2)0]groups(P<O.O1).High-level crotonylation modification is related to the proliferation of BPH tissue and the urodynamic performance of patients,which could be involved in the occurrence and development of BPH.

关 键 词：前列腺增生 巴豆酰化修饰 尿动力学 翻译后修饰 

分 类 号：R697.3[医药卫生—泌尿科学]