人乳头瘤病毒合并下生殖道病原菌感染与宫颈病变的相关性  

Correlation of HPV combined with lower genital tract pathogen infection and cervical lesion

作　　者：朱杰科 周鹏[1] 罗瑛 吴茂锋 禤淑霞 陈晨[1] 齐花欣 欧阳煜 尹卫国 ZHU Jieke;ZHOU Peng;LUO Ying;WU Maofeng;XUAN Shuxia;CHEN Chen;QI Huaxin;OUYANG Yu;YIN Weiguo(Department of Clinical Laboratory,Qingyuan People's Hospital,Qingyuan Hospital,Guangzhou Medical University,Qingyuan 511518,Guangdong,China)

机构地区：[1]广州医科大学附属清远医院(清远市人民医院)检验医学部,广东清远511518

出　　处：《检验医学》2024年第11期1097-1100,共4页Laboratory Medicine

基　　金：清远市科技计划项目(221105177684826)。

摘　　要：目的探讨人乳头瘤病毒(HPV)合并沙眼衣原体(CT)、解脲脲原体(UU)等下生殖道病原微生物感染与宫颈病变程度的相关性。方法选取2019年8月—2021年1月广州医科大学附属清远医院935例17~73岁女性患者,其中241例(25.78%)患者已停经,453例(48.45%)确诊宫颈炎,92例(9.84%)确诊宫颈癌,宫颈上皮内瘤变(CIN)Ⅰ级、Ⅱ级、Ⅲ级分别为184例(19.68%)、68例(7.27%)、138例(14.76%)。采用荧光定量聚合酶链反应(PCR)检测所有患者阴道分泌物或宫颈分泌物CT和UU,有235例患者同时送检HPV基因分型和CT、UU检测。采用Pearson相关分析评估HPV合并下生殖道病原菌感染与宫颈病变的相关性。结果CT、UU感染与HPV感染有关[比值比(OR)值为1.16,P<0.001];CT、UU感染者和未感染者高危型HPV、低危型HPV感染率差异有统计学意义(P<0.05);高危型HPV合并CT、UU感染与低危型HPV合并CT、UU感染患者宫颈病变发生率差异有统计学意义(P<0.05)。结论高危型HPV合并CT、UU感染与宫颈病变的发生、发展有一定关系。Objective To investigate the relationship between human papillomavirus(HPV)infection with Chlamydia trachomatis(CT)and Ureaplasma urealyticum(UU)lower genital tract pathogen infections and cervical lesion.Methods From August 2019 to January 2021,935 female patients,aged 17-73 years old,were enrolled from Qingyuan Hospital of Guangzhou Medical University.There were 241 cases of menelipsis(25.78%),453 cases of cervicitis(48.45%),92 cases of cervical cancer(9.84%),184 cases of cervical intraepithelial neoplasia(CIN)Ⅰ(19.68%),68 cases of CINⅡ(7.27%)and 138 cases of CINⅢ(14.76%).CT and UU of vaginal or cervical secretions were determined by fluorescence quantitative polymerase chain reaction(PCR).HPV genotyping and CT and UU determinations were performed in 235 patients.Pearson correlation analysis was used to evaluate the correlation between HPV combined with lower genital tract pathogen infection and cervical lesion.Results CT and UU infections were correlated with HPV infection,and the odds ratio(OR)was 1.16(P<0.001).The infection rates of high-risk HPV and low-risk HPV had statistical significance between CT and UU infected and uninfected subjects(P<0.05).The cervical lesion caused by high-risk HPV combined CT and UU infections had statistical significance from those caused by low-risk HPV combined CT and UU infections(P<0.05).Conclusions High-risk HPV combined with CT and UU infections may be related to the occurrence and development of cervical lesion.

关 键 词：人乳头瘤病毒 宫颈癌 宫颈上皮内瘤变 下生殖道 病原菌 

分 类 号：R373.9[医药卫生—病原生物学]