对亚甲基苯醌的不对称1,6-共轭加成反应研究进展  

Research Progress in Asymmetric 1,6-Conjugated Addition Reactions of p-Quinone Methides

作　　者：牛佳盼 武金丹 冯传密 王聪[1] NIU Jiapan;WU Jindan;FENG Chuanmi;WANG Cong(China Tianchen Engineering Corporation,Tianjin 300400,China)

机构地区：[1]中国天辰工程有限公司,天津300400

出　　处：《化学与生物工程》2024年第12期24-29,共6页Chemistry & Bioengineering

摘　　要：对亚甲基苯醌作为一种重要的醌类化合物,在极化为两性离子结构后活性很高,极易与亲核试剂发生1,6-共轭加成反应。从不同催化体系综述了对亚甲基苯醌参与不对称1,6-共轭加成反应的研究进展,并对生成的偕二芳基手性化合物的合成转化进行了总结,为相关药物的研发提供了指导。As a kind of important quinone compounds,p-quinone methides exhibit high activity after polarization into a zwitterionic structure and are prone to undergo 1,6-conjugated addition reactions with nucleophilic reagents.In this paper,we review the research progress of asymmetric 1,6-conjugated addition reactions involving p-quinone methides from different catalytic systems,and summarize the synthesis and transformation of the generated chiral compounds with gem-diaryl groups,which provide guidance for the research and development of related medicines.

关 键 词：对亚甲基苯醌 不对称1 6-共轭加成反应 亲核加成反应 

分 类 号：O62[理学—有机化学]