外周血嗜酸性粒细胞与老年高血压合并左心室肥厚的相关性研究  

Correlation of peripheral blood eosinophils with left ventricular hypertrophy in elderly patients with hypertension

作　　者：高银凤 张晨[1] 席小青[1] 孟军红 霍建婷 罗文利[1] Gao Yinfeng;Zhang Chen;Xi Xiaoqing;Meng Junhong;Huo Jianting;Luo Wenli(Department of General Medicine,the First Affiliated Hospital of Shihezi University,Shihezi832000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]石河子大学第一附属医院全科医学科,832000

出　　处：《中华老年心脑血管病杂志》2024年第12期1396-1400,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：2022年自治区重点研发计划项目(2022B03009-1)。

摘　　要：目的探讨外周血嗜酸性粒细胞(eosinophil,EOS)与老年高血压合并左心室肥厚(left ventricular hypertrophy,LVH)的相关性。方法随机选取2023年1~12月石河子大学第一附属医院全科医学科收治的老年高血压患者711例,采用回顾性横断面分析方法,将所有患者根据EOS计数分为1组128例(EOS<100×10^(6)/L)、2组385例[EOS(100~190)×10^(6)/L]、3组198例(EOS>190×10^(6)/L)。比较3组一般临床资料、生化指标、超生心动图指标,采用Separman相关分析EOS与各指标的相关性,采用logistic回归分析高血压合并LVH的影响因素。结果3组吸烟史、三酰甘油、尿酸、淋巴细胞计数逐渐升高,高密度脂蛋白胆固醇水平逐渐降低,差异有统计学意义(P<0.05,P<0.01);3组β受体阻滞剂、钙离子通道阻滞剂、他汀类药物比例比较逐渐升高,差异有统计学意义(P<0.05,P<0.01);3组左心室质量、左心室质量指数、室间隔厚度、左心室舒张末期内径、左心室后壁厚度逐渐显著升高,差异有统计学意义(P<0.01);EOS与左心室舒张末期内径、左心室后壁厚度、室间隔厚度、左心室质量指数、左心室质量、吸烟、尿酸、三酰甘油、白细胞计数、淋巴细胞计数、单核细胞计数、β受体阻滞剂、钙离子通道阻滞剂、他汀类药物呈正相关,与高密度脂蛋白胆固醇呈负相关(P<0.05,P<0.01)。二元logistic回归分析显示,女性、高密度脂蛋白胆固醇是老年高血压患者合并LVH的保护因素,年龄、EOS是老年高血压患者合并LVH的危险因素(OR=0.149,95%CI:0.096~0.230;OR=0.632,95%CI:0.399~0.999;OR=1.034,95%CI:1.007~1.062;OR=1.956,95%CI:1.446~2.645)。结论在老年高血压合并LVH患者中,女性、高密度脂蛋白胆固醇是保护因素,年龄、EOS是危险因素,EOS与老年高血压合并LVH的发生具有相关性。Objective To investigate the correlation between peripheral blood eosinophil(EOS)and left ventricular hypertrophy(LVH)in elderly patients with hypertension.Methods A retrospective cross-section analysis was conducted on 711 elderly hypertensive patients admitted to our department from January to December 2023.According to their EOS count,they were divided into Group 1(<100×10^(6)/L),Group 2[(100-190)×10^(6)/L]and Group 3(>190×10^(6)/L).The general clinical data,biochemical indicators,and echocardiographic parameters were compared among the three groups.The correlation between EOS and each indicator was analyzed by using Spearman correlation analysis.Logistic regression analysis was employed to identify the influential factors for hypertension complicated with LVH.Results Smoking history,TG and UA levels,and lymphocyte counts were gradually increased,while HDL-C level was gradually decreased in the three groups with the increment of EOS count(P<0.05,P<0.01).The proportions of usingβ-blockers,calcium channel blockers and statins were gradually increased in the three groups(P<0.05,P<0.01),so were the values of LVM,LVMI,IVST,LVEDD and LVPWT in them(P<0.01).EOS count was positively correlated with the values of LVM,LVMI,IVST,LVEDD and LVPWT,smoking history,TG and UA levels,WBC,lymphocyte and monocyte counts,and ratios of usingβ-blockers,calcium channel blockers and statins,but negatively with HDL-C level(P<0.05,P<0.01).Binary logistic regression analysis showed that female and HDL-C were protective factors for LVH in hypertensive patients,while age and EOS count were risk factors(OR=0.149,95%CI:0.096-0.230;OR=0.632,95%CI:0.399-0.999;OR=1.034,95%CI:1.007-1.062;OR=1.956,95%CI:1.446-2.645).Conclusion In elderly hypertensive patients with LVH,female and HDL-C are the protective factors,while age and EOS are the risk factors.EOS has a certain correlation with the occurrence of LVH in elderly hypertensive patients.

关 键 词：高血压 数据相关性 嗜酸性粒细胞 左心室肥厚 

分 类 号：R544.1[医药卫生—心血管疾病]