血清尿酸水平升高对高甘油三酯血症的影响  

The impact of elevated serum uric acid levels on hypertriglyceridemia

作　　者：缪淑贤 卢英 MIAO Shuxian;LU Ying(Department of Laboratory Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;Department of Medical Laboratory Science,the First Clinical Medical College,Nanjing Medical University,Nanjing 210029;National Center for Clinical Medicine and Laboratory Medicine Research,Sub-center of Jiangsu,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院检验学部,江苏南京210029 [2]南京医科大学第一临床医学院医学检验学系,江苏南京210029 [3]国家医学检验临床医学研究中心分中心,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2024年第12期1702-1707,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：“十四五”江苏省医学重点学科(ZDXK2022394)。

摘　　要：目的:探讨血清尿酸(uric acid,UA)水平与高甘油三酯血症(hypertriglyceridemia,HTG)之间的关系。方法:回顾性分析2023年参与研究的11 206例临床数据。采用多因素Logistic回归分析探讨UA水平和HTG之间的关系。应用广义线性模型、平滑曲线拟合和阈值效应分析研究UA水平和HTG之间的非线性关系。结果:共纳入11 206例研究对象,根据甘油三酯水平分为HTG组(n=3 410)和非HTG组(n=7 796)。校正混杂因素后,多因素Logistic回归模型显示,lnUA升高与HTG的风险正相关。将lnUA根据四分位数分为4层,最低四分位数(Q1)OR=1.000,第二四分位数(Q2)OR=1.557(95%CI:1.349~1.796),P <0.001,第三四分位数(Q3)OR=1.977(95%CI:1.712~2.283),P <0.001,最高四分位数(Q4)OR=3.101(95%CI:2.672~3.598),P <0.001,各层之间保持一致,lnUA和HTG之间存在很强的正相关性。平滑曲线拟合展示UA水平与HTG之间呈现非线性关系。lnUA与HTG呈U型关联的拐点为5.517,拐点右侧的效应高于左侧[4.692(95%CI:3.747~5.875)vs. 2.766(95%CI:1.869~4.094)]。结论:血清UA水平与HTG呈正相关。考虑到UA可能是HTG的一个危险因素,被诊断为HTG的个体应优先考虑UA水平的日常管理。Objective:To investigate the relationship between serum uric acid(UA)levels and hypertriglyceridemia(HTG).Methods:A retrospective analysis was conducted on clinical data from 11206 participants in a study conducted in 2023.Multivariate logistic regression analysis was used to explore the relationship between UA levels and HTG.Generalized linear models,smooth curve fitting,and threshold effect analysis were applied to investigate the nonlinear relationship between UA levels and HTG.Results:The study included 11,206 participants,divided based on TG levels into a HTG group(n=3410)and a non⁃HTG group(n=7796).After adjusting for confounders,the multivariate logistic regression model showed a positive correlation between elevated lnUA and the risk of HTG.The lnUA values were categorized into four quartiles:the lowest quartile Q1(OR=1.000),the second quartile Q2(OR=1.557,95%CI:1.349-1.796,P<0.001),the third quartile Q3(OR=1.977,95%CI:1.712-2.283,P<0.001),and the highest quartile Q4(OR=3.101,95%CI:2.672-3.598,P<0.001).A strong positive correlation was observed between lnUA and HTG across all quartiles.Smooth curve fitting demonstrated a nonlinear relationship between UA levels and HTG.The turning point of the U⁃shaped association between lnUA and HTG was found at 5.517,with the effect size on the right side being being higher than on the left side[4.692(95%CI:3.747-5.875)vs.2.766(95%CI:1.869-4.094)].Conclusion:Serum UA levels are positively correlated with HTG.Given that UA may be a risk factor for HTG,individuals diagnosed with HTG should prioritize the daily management of UA levels.

关 键 词：尿酸 甘油三酯 高甘油三酯血症 代谢性疾病 

分 类 号：R589[医药卫生—内分泌]