支气管哮喘发病机制相关细胞信号通路的研究进展  

Research Progress on Cellular Signaling Pathways Related to the Pathogenesis of Bronchial Asthma

作　　者：罗红英 李强[1] 刘海萍 刘莉 朱俊俊 许发功 晋文蔓[3] LUO Hongying;LI Qiang;LIU Haiping;LIU Li;ZHU Junjun;XU Fagong;JIN Wenman(Qinghai Provincial Hospital of Traditional Chinese Medicine,Qinghai Xining 810000,China;Qinghai University,Qinghai Xining 810016,China;First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China)

机构地区：[1]青海省中医院,青海西宁810000 [2]青海大学,青海西宁810016 [3]天津中医药大学第一附属医院,天津300381

出　　处：《中医药临床杂志》2024年第11期2223-2228,共6页Clinical Journal of Traditional Chinese Medicine

基　　金：青海省卫生健康委指导性课题(2022-wjzdx-18)。

摘　　要：哮喘(bronchial asthma,BA)是一种复杂的慢性气道炎症性疾病,其特征为气道高反应、嗜酸性粒细胞浸润、可逆性气流阻塞、气道重塑、粘液分泌过多和杯状细胞增生。通常表现为喘息、咳嗽和呼吸困难。近年来,信号通路的靶向治疗已显示出作为治疗该疾病的新策略。文章将从参与哮喘发病机制密切相关的细胞信号通路进行系统综述,以期为临床防治哮喘提供参考。Bronchial asthma(BA)is a complex chronic inflammatory disease of the airways,characterized by airway hyperresponsiveness,eosinophil infiltration,reversible airflow obstruction,airway remodeling,excessive mucus secretion,and goblet cell proliferation.Usually manifested as wheezing,coughing,and difficulty breathing.In recent years,targeted therapy of signaling pathways has been shown as a new strategy for treating this disease.This article will provide a systematic review of cell s ignaling pathways closely related to the pathogenes is of asthma,with the aim of providing potential targets for the clinical development of new drugs for the treatment of asthma.

关 键 词：哮喘 发病机制 信号通路 综述 

分 类 号：R245.3[医药卫生—针灸推拿学]