利多卡因CRI对犬麻醉效果的评估  

Anesthetic Evaluation of the Lidocaine with Continuous Rate of Infusion on Canines

作　　者：熊款款 吴映欣 沙宇 汤新维 杨凌宸[1,2] XIONG Kuankuan;WU Yingxin;SHA Yu;TANG Xinwei;YANG Lingchen(College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,China;Changsha Puyue Pet Clinic,Changsha 410100,China)

机构地区：[1]湖南农业大学动物医学院,长沙410128 [2]长沙普悦动物医院,长沙410100

出　　处：《经济动物学报》2024年第4期339-344,共6页Journal of Economic Animal

基　　金：国家自然科学基金项目(31802252);湖南省教育厅优秀青年项目(18B113)。

摘　　要：为评估不同剂量的利多卡因恒速静脉滴注(CRI)对犬麻醉效果的影响。以丙泊酚作为诱导麻醉剂,异氟烷作为维持麻醉剂,术中恒速静脉滴注不同剂量的利多卡因,检测犬的生理指标和疼痛反射,评估麻醉效果,确定利多卡因的最适浓度,根据试验结果制定合理、安全、可行的利多卡因CRI辅助麻醉方案,并运用到临床手术。结果表明:4 mg/kg的利多卡因CRI对犬具有较好的镇痛效果,在该剂量下,犬的体温、心率、呼吸率和血压均处于正常值。说明制定的利多卡因CRI镇痛流程可用于外科手术中的全身疼痛管理,可为兽医麻醉标准流程的制定提供参考。The aim of this study is to evaluate the anesthetic effect of different doses of continuous rate infusion of lidocaine on canines.In this experiment,propofol was used as the induced anesthetics,isoflurane as the maintained anesthetics,and different concentrations of lidocaine were injected into the intravenous drip at constant speed during the operation.The optimal concentration of lidocaine was finally determined by the physiological indicators,pain reflex of the canines,and the anesthetic effects.According to the experimental results,a reasonable,safe and feasible concentration of lidocaine CRI assisted anesthesia program was developed and applied in clinical surgery.The results showed that 4 mg/kg lidocaine CRI had a good analgesic effect on canines,and the body temperature,heart rate,respiration rate and blood pressure were all normal with this dose.It indicated that the lidocaine CRI procedure developed in this study could be used for general pain management in surgery,and the anesthetic procedure developed in this study provided the reference for the establishment of standard procedures for veterinary anesthesiology.

关 键 词：犬 利多卡因 恒速静脉滴注 镇痛 

分 类 号：S857.12[农业科学—临床兽医学]