疱疹病毒UL24蛋白研究进展  

Research Progress on the Function of Herpesvirus UL24 Protein

作　　者：张茜 李波 崔占鼎 牛江婷 伊淑帅 陈晓学莹 滕月 胡桂学[1] ZHANG Qian;LI Bo;CUI Zhanding;NIU Jiangting;YI Shushuai;CHEN Xiaoxueying;TENG Yue;HU Guixue(College of Veterinary Medicine,Jilin Agricultural University,Changchun 130118,China;Panjin Modern Agriculture Development Center,Panjin 124000,China;College of Animal Science and Technology,Jilin Agricultural Science and Technology University,Jilin 132101,China)

机构地区：[1]吉林农业大学动物医学院,长春130118 [2]盘锦市现代农业发展中心,盘锦124000 [3]吉林农业科技学院动物科技学院,吉林132101

出　　处：《经济动物学报》2024年第4期366-370,共5页Journal of Economic Animal

基　　金：国家重点研发计划项目(2016YFD0501002)。

摘　　要：疱疹病毒高度保守的UL24蛋白是病毒毒力决定因子之一,参与疱疹病毒感染多个阶段。疱疹病毒的UL24蛋白具有参与免疫逃逸、影响细胞周期、参与膜融合和核仁修饰的功能。此外,UL24蛋白还可以与其他蛋白相互作用发挥功能。对UL24蛋白及其功能进行综述,以期为疱疹病毒致病机制、疫苗研发和UL24蛋白功能的研究提供理论参考。The highly conserved UL24 protein of herpesvirus is one of the determinants of viral virulence and is related to many processes of herpesvirus infection.In recent years,studies have found that the UL24 protein of herpesvirus has the functions of participating in the immune escape,affecting the cell cycle,participating in membrane fusion,and modifying nucleoli.In addition,UL24 protein can also interact with other host cell proteins to play its functions.This article reviews the UL24 protein and its functions in order to provide a theoretical reference for the in-depth study of the pathogenic mechanism of the herpesvirus,the development of vaccines,and the functions of UL24 protein.

关 键 词：疱疹病毒 UL24蛋白 病毒复制 免疫逃逸 

分 类 号：S852.65[农业科学—基础兽医学]