环境健康效应研究的新技术与新方法  

New techniques and methods for study of environmental health effects

作　　者：张夏男[1] 吴申申 孟庆涛 李晓波 陈瑞 陈汉清 ZHANG Xianan;WU Shenshen;MENG Qingtao;LI Xiaobo;CHEN Rui;CHEN Hanqing(Yanjing Medical College,Capital Medical University,Beijing 101300,China;School of Public Health,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学燕京医学院,北京101300 [2]首都医科大学公共卫生学院,北京100069

出　　处：《环境与职业医学》2024年第10期1083-1086,共4页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金杰出青年基金项目:(82025031);国家自然科学基金重点项目(82230109);国家自然科学基金面上项目(32171370)。

摘　　要：环境污染物所致的健康效应是目前重大公共卫生问题之一。以人群作为研究对象的研究方法受限于可靠的人群队列,以单个分子作为靶标的研究方法不能全面反映环境污染物胁迫下的生物健康效应。利用高通量组学技术、机器学习、表观遗传检测等技术在不同生物学维度上对细胞、类器官、组织、整体动物、人群开展有针对性的联合分析及研究,将有助于为环境污染物潜在的生物学效应及干预靶点研究提供数据支撑,进而为环境污染物的风险评估和安全性评价提供理论依据。The health effects associated with environmental pollutants remain one of the major public health issues at present.The research method focusing on the population as the research subjects is limited by reliable cohorts,and the research method targeting individual molecules cannot fully reflect the biological health effects under environmental pollutant stress.Using high-throughput multi-omics,machine learning,and epigenetic detection to conduct targeted research and joint analysis on cells,organoids,organs,animals,and humans in different biological dimensions will help provide data support for the study of potential targets and biological effects of environmental pollutants,providing a theoretical basis for the risk assessment and safety evaluation of environmental pollutants.

关 键 词：环境健康效应 高通量组学 替代毒理学 计算毒理学 表观遗传 

分 类 号：R12[医药卫生—环境卫生学]