组蛋白乙酰化修饰在间充质干细胞衰老中的研究进展  

Research progress on histone acetylation modification in the aging of mesenchymal stem cells

作　　者：蒋旻 周游[2] 熊伟[3] 郭澍[2] Jiang Min;Zhou You;Xiong Wei;Guo Shu(Clinical Medicine,China Medical University,Shenyang 110001,China;Department of Plastic Surgery,the First Hospital of China Medical University,Shenyang 110001,China;Department of Plastic Surgery,the First Affiliated Hospital of Shihezi University School of Medicine,Shihezi 832008,China)

机构地区：[1]中国医科大学临床医学专业,沈阳110001 [2]中国医科大学附属第一医院整形外科,沈阳110001 [3]石河子大学医学院第一附属医院整形外科,石河子832008

出　　处：《中华整形外科杂志》2024年第11期1242-1248,共7页Chinese Journal of Plastic Surgery

基　　金：辽宁省"兴辽英才计划"项目(XLYC2002103)。

摘　　要：间充质干细胞(MSCs)的衰竭是衰老导致的组织和器官再生能力下降的重要原因之一。组蛋白乙酰化修饰水平的改变是衰老MSCs生物学特征改变的关键机制,针对性地修复衰老MSCs的异常组蛋白乙酰化修饰有望成为抗衰老治疗的有效方案。该文就组蛋白乙酰化酶和组蛋白去乙酰化酶在MSCs衰老过程中的作用机制进行综述,为抗衰老治疗提供了新的思路。The decline in the regenerative capacity of tissues and organs due to aging is significantly attributed to the failure of mesenchymal stem cells(MSCs).Changes in histone acetylation levels are a key mechanism underlying the biological characteristics of aging MSCs.Targeted repair of abnormal histone acetylation in aging MSCs holds promise as an effective treatment for anti-aging therapy.This article reviews the roles of histone acetylases and histone deacetylases in the aging process of MSCs,aiming to provide new insights for anti-aging therapy.

关 键 词：衰老 间充质干细胞 组蛋白类 组蛋白乙酰化修饰 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]