共价有机框架材料在药物递送领域的应用研究进展  

Research Progress on Applications of Covalent Organic Framework Materials in the Field of Drug Delivery

作　　者：刘际芳 梁旭华 孔令妍 程敏 付爱根 LIU Jifang;LIANG Xuhua;KONG Lingyan;CHENG Min;FU Aigen(College of Life Sciences,Northwest University,Xi’an 710069;College of Biology Pharmacy and Food Engineering,Shangluo University,Shangluo 726000;Shaanxi Qinling Industrial Technology Research Institute of Special Biological Resources,Shangluo 726000)

机构地区：[1]西北大学生命科学学院,陕西西安710069 [2]商洛学院生物医药与食品工程学院,陕西商洛726000 [3]陕西秦岭特色生物资源产业技术研究院,陕西商洛726000

出　　处：《中国医药工业杂志》2024年第11期1477-1484,共8页Chinese Journal of Pharmaceuticals

基　　金：陕西省科技创新团队项目(2022TD-56);陕西省重点研发计划项目(2020GY-313);陕西省中医药管理局秦创原中医药创新研发转化项目(2022-QCYZH-042);商洛学院科研创新团队项目(20SCX02)。

摘　　要：共价有机框架(COF)凭借高比表面积、均匀且可调的孔径以及易于修饰和功能化等特性,在药物递送领域备受瞩目。文章介绍了COF的制备方法,涵盖模板介导的共沉淀法、一锅合成法和原位掺杂法;并且阐述了其结构设计,包括智能刺激响应性分子设计和表面修饰等内容。此外,文章还概述了COF在抗肿瘤、抗菌及抗炎药物递送中的应用,旨在为基于COF的药物递送系统的快速发展提供启发性见解。Covalent organic frameworks(COFs)have attracted great attention in the field of drug delivery due to their characteristics such as high specific surface area,uniform and adjustable pore size,and facile modification and functionalization.This review introduces the preparation methods of COFs,including template-mediated coprecipitation method,one-pot synthesis method and in situ doping method.More over,this review elaborates the structural design of COFs,including intelligent stimuli-responsive molecular design and surface modification.In addition,this review also outlines the applications of COFs in the field of delivery of antineoplastic,antibacterial and anti-inflammatory drugs,aiming to provide insightful perspectives to facilitate the rapid development of COFs-based drug delivery systems.

关 键 词：共价有机框架 纳米技术 药物递送系统 特征设计 研究进展 

分 类 号：R944.9[医药卫生—药剂学]