影响汽化过氧化氢灭菌生物指示剂抗力的因素研究  

Research on Factors Affecting the Resistance of Biological Indicators for Vaporized Hydrogen Peroxide Sterilization

作　　者：叶项宇 邢倩倩 周婷 辛秋华 王云光 YE Xiangyu;XING Qianqian;ZHOU Ting;XIN Qiuhua;WANG Yunguang(Zhejiang Tailin Life Science Co.,Ltd.,Hangzhou 311401)

机构地区：[1]浙江泰林生命科学有限公司,浙江杭州311401

出　　处：《中国医药工业杂志》2024年第11期1572-1577,共6页Chinese Journal of Pharmaceuticals

摘　　要：嗜热脂肪地芽孢杆菌(Geobacillus stearothermophilus,ATCC 12980),通常作为生物指示物监测过氧化氢的灭菌效果。文章探究了在汽化过氧化氢灭菌条件下,载体光洁度、芽孢纯度对生物指示剂抗力的影响。结果表明,生物指示剂的芽孢纯度与抗力呈负相关;生物指示剂的载体光洁度低时会提高抗力。因此,用户在接收汽化过氧化氢灭菌生物指示剂时,除进行常规的芽孢数量复核外,还需关注生物指示剂的载体质量及芽孢纯度。Geobacillus stearothermophilus(ATCC 12980)is commonly used to detect the sterilization effect of vaporized hydrogen peroxide.The study mainly discussed the effects of carriers and spore purity on the resistance of biological indicators(BIs)under vaporized hydrogen peroxide sterilization.The results showed that spore purity was negatively correlated with BIs resistance,poor carrier smoothness could also increase the resistance of BIs.Therefore,when accepting the BIs which used to monitor the vaporized hydrogen peroxide sterilization,besides the viable spore count,users should pay more attention to the carrier and the purity of the spores.

关 键 词：生物指示剂 灭菌 过氧化氢 芽孢纯度 载体光洁度 

分 类 号：R187[医药卫生—流行病学]