miR-182及其靶基因在HIV/AIDS患者气阴两虚证炎症反应中的作用机制  

Mechanism of miR-182 and its target gene in the infammatory response of HIV/AIDS syndrome of Qi-Yin deficiency

作　　者：潘万旗[1] 张淼[1] 刘飒[1] 许前磊[2,3] 谢露 马素娜 王娟[1] 郭会军[2,3] PAN Wanqi;ZHANG Miao;LIU Sa;XU Qianlei;XIE Lu;MA Suna;WANG Juan;GUO Hujun(Henan Universily of Chinese Medicine,Zhengzhow 450046,Henan,China;The First AMfiared Hospital of Henan University of Chinese Medicine,Zhengzhou 450000.Henan,China;Henan Key Laboralory of Viral Diseases Prevention and Treatment of Chinese Medicine,Zhengzhou 450008.Henan,China)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第一附属医院,郑州450000 [3]河南省病毒性疾病中医药防治重点实验室,郑州450008

出　　处：《中国艾滋病性病》2024年第11期1202-1205,共4页Chinese Journal of Aids & STD

基　　金：国家自然科学基金资助项目(82274474,81804060);中原领军人才项目(ZYYCYU2020119);河南省科技攻关(212102311119);河南中医药大学科研苗圃工程项目(MP2020-09);河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-2023-1-30)。

摘　　要：气阴两虚证为HIV/AIDS患者常见基本证候之一,运用基因芯片技术发现miR-182及其靶基因在HIV/AIDS患者气阴两虚证中异常表达。本文通过探讨miR-182调控炎症反应的作用与miR-182异常表达靶基因的功能,阐释miR-182及其靶基因在炎症反应与HIV/AIDS患者气阴两虚证炎症反应中可能的作用机制,为深入研究HIV/AIDS患者炎症反应的发生机制奠定基础。Qi-Yin deficiency syndrome is one of the common basic syndromes of HIV/AIDS.miR-182 and its target genes are abnormally expressed in Qi-Yin deficiency syndrome of HIV/AIDS by gene chip technology.This article discussed the role of miR-182 in regulating inflammation and the function of the abnormal expression of miR-182 target genes,and explained the possible mechanism of miR-182 and its target genes in inflammation and HIV/AIDS inflammation in Qi-Yin deficiency syndrome,thus laying the foundation for further research on the pathogenesis of HIV/AIDS inflammation.

关 键 词：艾滋病病毒感染者/艾滋病患者 气阴两虚证 miR-182 炎症反应 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]