抗反转录病毒治疗对HIV/AIDS患者代谢综合征影响的研究进展  

Research progress on the impact of antiretroviral therapy on metabolic syndrome in people living with HIV

作　　者：杨红红 余庆 李梅[1] 刘倩 田时运 YANG Honghong;YU Qing;LI Mei;LIU Qian;TIAN Shiyun(Chongqing Public Health Medical Center,Chongqing 400036,China)

机构地区：[1]重庆市公共卫生医疗救治中心,重庆400063

出　　处：《中国艾滋病性病》2024年第11期1206-1210,共5页Chinese Journal of Aids & STD

基　　金：重庆市首批公共卫生重点学科(专科);重庆市科卫联合医学科研项目(2024MSXM149)。

摘　　要：HIV/AIDS患者合并代谢综合征(MS)已成为重大公共卫生问题,引起了广泛关注。HIV/AIDS患者MS的发病机制尚不明确。较多研究发现cART药物与MS的每个构成条件存在相互关联,了解MS与cART药物使用之间的关系十分重要。不同cART药物导致HIV/AIDS患者发生MS的风险程度不同,对MS的各个组成部分的影响亦不尽相同,研究结果存在较大差异。本文通过阐述cART药物对MS各个组成部分的影响,即不同cART药物对体重、血糖、血脂和血压水平的影响,以期利用不同cART药物各自的特点,为患者制定个体化的治疗方案,从而减少他们的心脑血管发病率和死亡率,提高生活质量。The coexistence of metabolic syndrome(MS)in people living with HIV(PLWH)has emerged as a major public health issue,attracting considerable attention.The pathogenesis of MS in PLWH remains unclear.Numerous studies have indicated a complex interplay between combination antiretroviral therapy(cART)and the various components of MS,making it crucial to understand the relationship between MS and cART usage.Different cART regimens pose different risks for the development of MS in PLWH and have different effects on different components of the syndrome.However,research findings on this topic remain inconsistent.This article reviews the effects of cART drugs on the individual components of MS,including their effects on body weight,blood glucose,blood lipids,and blood pressure levels,with the aim of using the specific characteristics of different cART regimens to tailor individual treatment plans for patients.Such personalization could help to reduce cardiovascular morbidity and mortality,thereby improving the quality of lifeof PLWH.

关 键 词：抗反转录病毒治疗 艾滋病病毒感染者/艾滋病患者 代谢综合征 危险因素 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]