姜黄素对LPS诱导体外巨噬细胞分泌TNF-α影响的meta分析  

A Meta-analysis of the Effect of Curcumin on TNF-αExpression in Macrophages Induced by LPS

作　　者：邓琴[1] 周智兴[1] 韩晓群[1] DENG Qin;ZHOU Zhi-xing;HAN Xiao-qun(Medical College of Yichun University,Yichun 336000,China)

机构地区：[1]宜春学院医学院,江西宜春336000

出　　处：《宜春学院学报》2024年第9期62-65,共4页Journal of Yichun University

基　　金：江西省卫生健康委科技项目(编号:202212700)。

摘　　要：目的:探讨姜黄素对脂多糖(LPS)诱导巨噬细胞产生细胞因子TNF-α的影响。方法:检索国内外全文数据库有关姜黄素与细胞因子TNF-α浓度关系的文献,检索起止时间均从建库至2023年11月,采用RevMan 5.3分析软件对文献资料进行定量综合。结果:根据文献纳入和排除标准,共纳入8篇相关文献;荟萃分析表明,姜黄素+LPS组与LPS组相比,巨噬细胞产生的TNF-α浓度差异有统计学意义(P<0.05),合并后总体MD值为-506.336,95%CI为(-770.06~-242.66);各研究之间存在较强的异质性,亚组分析发现巨噬细胞种类是异质性重要来源。结论:姜黄素能够抑制激活的巨噬细胞产生炎症因子TNF-α,这可能是姜黄素的抗炎机制之一。Objective:To investigate the effect of curcumin on TNF-α secreted by macrophages induced by lipopolysaccharide(LPS).Methods:Literature on the relationship between curcumin and cytokine TNF-α concentration in full-text databases were searched and the search starts from the database construction to November 2023.Quantitative synthesis of the literature data was performed using RevMan5.3 analysis software.Results:According to the inclusion and exclusion criteria of the literature,a total of 8 related articles were included.The meta-analysis results showed that the difference in TNF-α concentrations produced by macrophages in the curcumin+LPS group compared with the LPS group was significant(P<0.05).The combined overall MD value was-506.336,with a 95%CI of(-770.06 to-242.66).There was strong heterogeneity among the studies,and the subgroup analysis revealed that macrophage species were an important source of heterogeneity.Conclusion:Curcumin is able to inhibit the production of the inflammatory factor TNF-α by activated macrophages,which may be one of the anti-inflammatory mechanisms of curcumin.

关 键 词：姜黄素 巨噬细胞 TNF-Α META分析 

分 类 号：R310.34[医药卫生—基础医学]