加用活血归元汤加味治疗慢性胃炎伴抑郁临床研究  

Clinical Effect of the Combining Use of Modified Huoxue Guiyuan Decoction on Chronic Gastritis with Depression

作　　者：王红霞 付凯 李昆仑 WANG Hong-xia;FU Kai;LI Kun-lun(Kaifeng Municipal Hospital of Traditional Chinese Medicine,Kaifeng,Henan,475000)

机构地区：[1]开封市中医院,河南开封475000

出　　处：《广西中医药大学学报》2024年第6期16-20,共5页Journal of Guangxi University Of Chinese Medicine

摘　　要：[目的]探讨加用活血归元汤加味治疗慢性胃炎(chronic gastritis,CG)伴抑郁的临床效果。[方法]选取118例CG伴抑郁患者,按随机数字表法分为联合组、对照组各59例,对照组采用西医综合疗法,联合组在对照组基础上联合活血归元汤加味治疗,疗程为2个月。对比两组疗效、中医症状评分、简单自测抑郁量表(PHQ-9)评分、复发率以及血清炎症因子[单核细胞趋化蛋白-1(MCP-1)、白细胞介素(IL)-8、IL-32]水平。[结果]联合组总有效率为98.31%,对照组为86.44%,联合组疗效优于对照组(P<0.05);随访2个月联合组的复发率为1.69%,对照组为15.25%,差异有显著性意义(P<0.05)。治疗2个月后联合组胃脘或胁肋胀痛、腹胀、食少纳呆、便溏不爽、情绪抑郁、急躁易怒等中医症状评分均低于对照组(P<0.05),联合组PHQ-9评分低于对照组(P<0.05);联合组MCP-1、IL-8、IL-32水平低于对照组(P<0.05)。[结论]加用活血归元汤加味治疗CG伴抑郁患者,可有效改善临床症状,减轻机体炎症反应。[Objective]To investigate the clinical effectiveness of the combining use of modified Huoxue Guiyuan decoction in the treatment of chronic gastritis(CG)accompanied by depression.[Methods]By the random number table method,118 patients with CG and depression were randomly divided into a combined treatment group and a control group,with 59 patients in each.The control group received comprehensive western medicine therapy,while the combined treatment group received the treatment of the modified Huoxue Guiyuan decoction in addition to the same western medicine treatment in the control group.The course of treatment lasted for 2 months.Comparisons were made between the two groups in terms of efficacy,traditional Chinese medicine(TCM)symptom scores,patient health questionnaire-9(PHQ-9)scores,recurrence rates,and serum levels of inflammatory cytokines[monocyte chemoattractant protein-1(MCP-1),interleukin(IL)-8,and IL-32].[Results]The total effective rate was 98.31%in the combined treatment group and 86.44%in the control group,indicating that the combined treatment group had superior efficacy(P<0.05).After a 2-month follow-up,the recurrence rate in the combined treatment group was 1.69%,which was significantly lower than the 15.25%in the control group(P<0.05).After 2 months of treatment,the combined treatment group had lower TCM symptom scores for epigastric or hypochondriac distension and pain,abdominal distension,anorexia,loose and sticky stool,emotional depression,irritability,and other symptoms compared to the control group(P<0.05).Additionally,the PHQ-9 scores in the combined treatment group were lower than those in the control group(P<0.05).The levels of MCP-1,IL-8,and IL-32 in the combined treatment group were also lower than those in the control group(P<0.05).[Conclusion]The combining use of modified Huoxue Guiyuan decoction can effectively improve the clinical symptoms and reduce inflammatory responses in the cases with CG accompanied by depression.

关 键 词：活血归元汤 慢性胃炎 抑郁 刘学勤 

分 类 号：R256.3[医药卫生—中医内科学]