认知障碍患者神经系统感染相关病毒抗体回顾性分析  

Retrospective analysis of virus antibodies related to nervous system infections in patients with cognitive impairment

作　　者：于丹葳 尼玛曲珍 马瑞敏[1] 刘杰 马淼 张国军[1] YU Danwei;NIMA Quzhen;MA Ruimin;LIU Jie;MA Miao;ZHANG Guojun(Clinical Diagnosis Center,Beijing Tiantan Hospital,Capital Medical University/Beijing Engineering Research Center of Immunological Reagents Clinical Research/NMPA Key Laboratory for Quality Control of In Vitro Diagnostics,Beijing 100070,China;Clinical Diagnosis College,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院实验诊断中心/北京市免疫试剂临床工程技术研究中心/国家药监局体外诊断质量控制重点实验室,北京100070 [2]首都医科大学临床检验诊断学系,北京100070

出　　处：《国际检验医学杂志》2024年第23期2823-2828,2833,共7页International Journal of Laboratory Medicine

基　　金：国家重点研发计划项目(2022YFC2403500)。

摘　　要：目的回顾性分析认知障碍患者体内神经系统感染相关病毒抗体特点,评估其与认知障碍的关系,并探讨病毒感染与认知障碍发生发展的关系。方法选取2019年6月至2023年6月就诊于首都医科大学附属北京天坛医院的170例轻度认知障碍患者作为轻度认知障碍组,208例认知障碍患者作为认知障碍组,143例痴呆患者作为痴呆组,另选取同期该院年龄性别相匹配的非感染性非炎症疾病的146例对照者作为对照组。检测患者血清和脑脊液中神经系统感染相关病毒抗体水平,比较抗体检出率、抗体水平并计算感染负荷,对所有患者进行认知功能评估,分析感染负荷与认知功能障碍程度的关系。结果3组认知障碍患者血清中Ⅰ型单纯疱疹病毒(HSV)-1 IgG检出率和抗体水平显著高于对照组(P<0.05),3组认知障碍患者血清中HSV(1+2)IgM检出率高于对照组(P<0.05),但其在轻度认知障碍组、认知障碍组和痴呆组之间差异无统计学意义(P>0.05)。3组认知障碍患者血清感染负荷高于对照组(P<0.05),且感染负荷越高,认知障碍程度越严重。结论病毒感染是认知障碍疾病的重要影响因素,HSV感染可能是认知功能障碍的促进因素。Objective To retrospectively analyze the characteristics of viral antibodies related to nervous system infections in patients with cognitive impairment,evaluate their relationship with cognitive impairment,and explore the relationship between viral infections and the occurrence and development of cognitive impairment.Methods A total of 170 mild cognitive impairment patients who visited Beijing Tiantan Hospital,Capital Medical University from June 2019 to June 2023 were selected as the mild cognitive impairment group,208 cognitive impairment patients were selected as the cognitive impairment group,143 dementia patients were selected as the dementia group,and 146 age-matched and gender-matched non infectious and non inflammatory disease controls during the same period in the hospital were selected as the control group.The levels of virus antibodies related to nervous system infections in the serum and cerebrospinal fluid of patients were detected,the detection rate and levels of antibodies were compared,and the infection burden was calculated.The cognitive function of all patients was evaluated and the relationship between infection burden and the degree of cognitive dysfunction was analyzed.Results The detection rate and antibody level of herpes simplex virus(HSV)1 IgG in the serum of three groups of patients with cognitive impairment were significantly higher than those in the control group(P<0.05).The detection rate of HSV(1+2)IgM in the serum of three groups of patients with cognitive impairment was higher than that in the control group(P<0.05),but there was no statistically significant difference between the mild cognitive impairment group,cognitive impairment group,and dementia group(P>0.05).The serum infection load of three groups of patients with cognitive impairment was higher than that of the control group(P<0.05),and the higher the infection load,the more severe the cognitive impairment.Conclusion Viral infection is an important influencing factor of cognitive impairment diseases,and HSV infection may be

关 键 词：认知障碍 单纯疱疹病毒 感染负荷 

分 类 号：R446.6[医药卫生—诊断学]