热性惊厥患儿外周血NLR、LDH水平与病情发作情况及脑损伤的关系研究  

Relationship between peripheral blood NLR and LDH level with seizures and brain damage in children with febrile convulsions

作　　者：赵乐 孙杰 冯晅 ZHAO Le;SUN Jie;FENG Xuan(Department of Pre-Hospital Emergency,Shanxi Provincial Children's Hospital(Shanxi Provincial Maternal and Child Health Hospital),Taiyuan,Shanxi 030000,China;Department of Infectious Diseases,Shanxi Provincial Children's Hospital(Shanxi Provincial Maternal and Child Health Hospital),Taiyuan,Shanxi 030000,China)

机构地区：[1]山西省儿童医院(山西省妇幼保健院)院前急救,山西太原030000 [2]山西省儿童医院(山西省妇幼保健院)感染性疾病科,山西太原030000

出　　处：《国际检验医学杂志》2024年第23期2878-2882,共5页International Journal of Laboratory Medicine

基　　金：山西省基础研究计划项目(202203021221289)。

摘　　要：目的 分析热性惊厥(FC)患儿中性粒细胞与淋巴细胞比值(NLR)、乳酸脱氢酶(LDH)水平与病情发作和脑损伤的关系。方法 选取2021年4月至2023年8月该院就诊的134例FC患儿为观察组,另选取该院同期134例呼吸道感染但不伴FC的患儿为对照组,FC患儿根据惊厥发作情况分为轻度组(惊厥发作次数<2次且持续时间<10 min,79例)与重度组(惊厥发作次数≥2次或持续时间≥10 min,55例)。对比两组NLR、LDH水平,采用Pearson相关性分析FC患儿NLR、LDH水平与惊厥发作情况的相关性;根据是否存在脑损伤,观察组再分为脑损伤组(38例)与无脑损伤组(96例),使用单因素、多因素Logistic回归分析影响患儿发生脑损伤的因素。结果 与对照组相比,观察组NLR、LDH水平更高(P<0.05);与轻度组相比,重度组NLR、LDH水平更高(P<0.05)。FC患儿NLR、LDH水平与惊厥持续时间、惊厥发作次数呈正相关(P<0.05)。与无脑损伤组相比,脑损伤组惊厥发作次数≥2次,惊厥持续时间≥10 min的患儿占比较大,NLR、LDH水平较高(P<0.05)。多因素Logistic回归分析显示,惊厥发作次数、惊厥持续时间及NLR、LDH水平均为影响FC患儿脑损伤的独立危险因素(P<0.05)。结论 FC患儿外周血NLR、LDH水平更高,NLR、LDH水平与惊厥发作情况呈正相关,惊厥发作次数、惊厥持续时间及NLR、LDH水平均为FC患儿出现脑损伤的危险因素。Objective To investigate the relationship between peripheral blood neutrophil-to-lymphocyte ratio(NLR) and lactate dehydrogenase(LDH) level with seizures and brain damage in children with febrile convulsions(FC).Methods A total of 134 children with FC in the hospital from April 2021 to August 2023 were selected as observation group.Another 134 children with respiratory tract infections but without FC from the same period in the hospital were selected as the control group.FC children were further classified into mild group(frequency<2 times and duration<10 min,79 cases) and severe group(frequency≥2 times or duration≥10 min,55 cases) according to the severity of seizures.NLR and LDH level between two groups were compared,Pearson correlation analysis was used to analyze the correlation between NLR,LDH level in FC children and seizures.FC children were re-divided into brain damage group(38 cases) and non-brain damage group(96 cases) according to the presence or absence of brain damage.Univariate and multivariate Logistic analysis were used to investigate the factors influencing the brain damage in children.Results NLR and LDH level were notably elevated in the observation group compared with the control group(P<0.05),and the NLR and LDH level were higher in the severe group compared with the mild group(P<0.05).NLR and LDH level in children with FC were positively correlated with the duration and frequency of seizures(P<0.05).Compared with the non-brain damage group,the proportion of children who had seizures ≥2 times and lasted ≥10 min and NLR and LDH level in the brain damage group were higher(P<0.05).Multivariate Logistic regression analysis denoted that the frequency of seizures,duration of seizures,NLR and LDH level were independent risk factors affecting brain damage in children with FC(P<0.05).Conclusion NLR and LDH level in peripheral blood of children with FC is positively correlated with the duration and frequency of seizures.Moreover,the frequency of seizures,duration of seizures,NLR and LDH level a

关 键 词：热性惊厥 中性粒细胞与淋巴细胞比率 乳酸脱氢酶 癫痫发作 脑损伤 

分 类 号：R446.1[医药卫生—诊断学]