Sestrin2、Survivin在急性心肌梗死患者血清中水平及其与冠状动脉病变的关系  

Serum levels of Sestrin2 and Survivin in patients with acute myocardial infarction and their relationship with coronary artery disease

作　　者：蒋卓玲 王苗苗 路舒婷 JIANG Zhuoling;WANG Miaomiao;LU Shuting(Hanzhong 3201 Hospital,Hanzhong,Shaanxi 723000,China;Disease Control Center of Hanzhong,Hanzhong,Shaanxi 723000,China)

机构地区：[1]陕西省汉中市三二〇一医院,陕西汉中723000 [2]陕西省汉中市疾病控制中心,陕西汉中723000

出　　处：《国际检验医学杂志》2024年第23期2913-2917,共5页International Journal of Laboratory Medicine

摘　　要：目的 探讨急性心肌梗死(AMI)患者血清Sestrin2、生存素(Survivin)水平及其与冠状动脉狭窄程度的相关性。方法 选取2020年10月至2022年12月在陕西省汉中市三二〇一医院收治的120例AMI患者为观察对象,其中ST段抬高型心肌梗死(STEMI)67例,非ST段抬高型心肌梗死(NSTEMI)53例,根据Gensini评分将患者分为轻度狭窄组与重度狭窄组,选择同期行冠状动脉造影(狭窄程度<50%)且不符合AMI诊断标准的患者60例作为对照组,采用酶联免疫吸附试验检测血清Sestrin2、Survivin水平,相关性分析采用Spearman法,受试者工作特征曲线分析血清Sestrin2、Survivin对重度狭窄AMI的诊断价值。结果 对照组、NSTEMI组、STEMI组脑钠肽、肌钙蛋白、肌酸激酶同工酶、左室射血分数、空腹血糖水平比较,差异有统计学意义(P<0.05);与对照组比较,NSTEMI组与STEMI组血清Sestrin2、Survivin水平显著升高(P<0.05);随着AMI患者冠状动脉病变支数及狭窄程度的增加,血清Sestrin2、Survivin水平逐渐升高(P<0.05);血清Sestrin2、Survivin水平与冠状动脉病变支数、SYNTAX评分及Gensini评分呈正相关(P<0.05);血清Sestrin2、Survivin单独及联合诊断重度狭窄AMI的曲线下面积(AUC)分别为0.840、0.823、0.920,联合诊断的AUC大于单项诊断(P<0.05)。结论 AMI患者血清Sestrin2、Survivin水平升高,与冠状动脉狭窄程度相关,可能成为评估冠状动脉病变程度的标志物。Objective To investigate the serum levels of Sestrin2 and Survivin in patients with acute myocardial infarction(AMI) and their correlation with the degree of coronary artery stenosis.Methods A total of 120 AMI patients admitted to Hanzhong 3201 Hospital from October 2020 to December 2022 were selected as the observation subjects,and there were 67 cases of ST-segment elevation myocardial infarction(STEMI) and 53 cases of non-ST-segment elevation myocardial infarction(NSTEMI).According to the Gensini score,patients were grouped into mild stenosis group and severe stenosis group,60 patients who underwent coronary angiography(stenosis degree <50%) at the same time and did not meet the diagnosis standard of AMI were regarded as the control group.The levels of serum Sestrin2 and Survivin were detected by enzyme linked immunosorbent assay,Spearman method was used for correlation analysis,and receiver operating characteristic curve was applied to analyze the diagnostic value of serum Sestrin2 and Survivin in severe stenotic AMI.Results There were statistically significant differences in brain natriuretic peptide,troponin,creatine kinase isoenzyme,left ventricular ejection fraction,fasting plasma glucose among the control group,NSTEMI group and STEMI group(P<0.05).Compared with the control group,the levels of serum Sestrin2 and Survivin in NSTEMI group and STEMI group were obviously higher(P<0.05).Serum Sestrin2 and Survivin levels increased with the increase of coronary artery lesion number and stenosis degree in AMI patients(P<0.05).Serum Sestrin2 and Survivin levels were positively correlated with the number of coronary lesions,SYNTAX score and Gensini score in AMI patients(P<0.05).The area under the curve(AUC) of serum Sestrin2 and Survivin in diagnosis of severe stenotic AMI alone and in combination were 0.840,0.823 and 0.920,respectively,and AUC of the combined detection was larger than those of singe detection(P<0.05).Conclusion The serum levels of Sestrin2 and Survivin in patients with AMI are increased,they are r

关 键 词：心肌梗死 Sestrin2 生存素 冠状动脉病变 

分 类 号：R542.2[医药卫生—心血管疾病]