TyG指数、AIP、SII与急性冠状动脉综合征及冠状动脉狭窄程度的关系  

Relationship between TyG index,AIP,SII with acute coronary syndrome and coronary artery stenosis degree

作　　者：申少梦 申亚晴 张丽娜 孟利民[1] 李敏[1] 刘丽军[1] SHEN Shaomeng;SHEN Yaqing;ZHANG Lina;MENG Limin;LI Min;LIU Lijun(Handan First Hospital,Handan,Hebei 056002,China)

机构地区：[1]河北省邯郸市第一医院,河北邯郸056002

出　　处：《国际检验医学杂志》2024年第23期2927-2931,共5页International Journal of Laboratory Medicine

基　　金：邯郸市科技研究与发展计划项目(23422080432C)。

摘　　要：目的 探讨三酰甘油葡萄糖乘积(TyG)指数、血浆动脉硬化指数(AIP)、系统性免疫炎症指数(SII)与急性冠状动脉综合征(ACS)患者病情及冠状动脉狭窄程度的关系。方法 回顾性分析2021年11月至2023年12月因疑诊冠心病在该院住院行冠状动脉血管造影术的患者,将其分为ACS组(1 446例)和对照组(690例),收集患者的一般基线资料和实验室资料,并计算TyG指数、AIP、SII;利用Gensini评分对患者冠状动脉狭窄程度进行评估;采用多因素Logistic回归分析方法确定ACS的危险因素;绘制受试者工作特征(ROC)曲线分析各指标对ACS患者冠状动脉狭窄程度的诊断价值。结果 ACS组TyG指数、AIP、SII明显高于对照组(P<0.05);通过多因素Logistic回归分析发现,TyG指数、AIP、SII是ACS的危险因素(P<0.05);通过绘制ROC曲线得出,TyG指数、AIP、SII对于ACS患者冠状动脉狭窄程度具有一定的诊断价值,通过TyG指数、AIP、SII的最佳截断值将所有患者再次分为不同亚组,结果显示,高TyG指数、AIP、SII组Gensini评分明显高于低TyG指数、AIP、SII组(P<0.05)。结论 TyG指数、AIP、SII与ACS有密切关系,可以作为诊断ACS的简便的实验室指标,同时还能对冠状动脉狭窄程度有较好的诊断价值。Objective To investigate the relationship between the triglyceride glucose product(TyG) index,plasma arteriosclerosis index(AIP),systemic immune inflammation index(SII),and the severity of acute coronary syndrome(ACS) and coronary artery stenosis degree in patients.Methods A retrospective analysis was conducted on patients who underwent coronary angiography at the hospital from November 2021 to December 2023 due to suspected coronary heart disease,and they were divided into an ACS group(1 446 cases) and a control group(690 cases).General baseline and laboratory data of the patients were collected,and TyG index,AIP and SII in were calculated.Gensini score was used to evaluate the degree of coronary artery stenosis.The risk factors of ACS were determined by binary multivariate Logistic regression analysis.Receiver operating characteristic(ROC) curve was drawn to analyze the diagnostic value of various indicators for the degree of coronary artery stenosis in ACS patients.Results TyG index,AIP and SII in ACS group were significantly higher than those in control group(P<0.05).Binary multivariate Logistic regression analysis results showed that TyG index,AIP and SII were risk factors for ACS(P<0.05).The ROC curve results showed that TyG index,AIP and SII had certain diagnostic value for the degree of coronary artery stenosis in ACS patients.According to the cut off values of TyG index,AIP,and SII,the patients were further divided into different subgroups,the Gensini scores in the high TyG index,AIP,and SII groups were significantly higher than those in the low TyG index,AIP,and SII groups(P<0.05).Conclusion TyG index,AIP and SII are closely related to ACS,which could be used as simple laboratory indexes for diagnosis of ACS,and also have good diagnostic value for the coronary artery stenosis degree.

关 键 词：三酰甘油葡萄糖乘积指数 血浆动脉硬化指数 系统性免疫炎症指数 急性冠状动脉综合征 

分 类 号：R446.1[医药卫生—诊断学]