免疫调节紊乱在职业紧张致动脉粥样硬化中的作用机制  

Mechanism of immune regulation disorder in the development of atherosclerosis induced by occupational stress

作　　者：陈靖 黄渝杰 颜源(综述) 尹扬光(审校) CHEN Jing;HUANG Yujie;YAN Yuan;YIN Yangguang(Department of Cardiovascular Medicine,The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College,Chongqing 400060,China)

机构地区：[1]重庆医药高等专科学校附属第一医院心血管内科,重庆400060

出　　处：《预防医学》2024年第12期1049-1051,共3页China Preventive Medicine Journal

基　　金：国家自然科学基金面上项目(82073523);重庆医药高等专科学校附属第一医院孵化基金重点项目(2022-2023ZD07)。

摘　　要：研究表明,职业紧张与动脉粥样硬化的发生、发展密切相关,免疫调节紊乱在职业紧张与动脉粥样硬化之间发挥中介效应。职业紧张引发机体免疫调节紊乱,通过介导免疫细胞和炎症介质激活、内皮细胞功能障碍、脂质代谢紊乱等途径,最终导致动脉粥样硬化。本文对免疫调节紊乱在职业紧张致动脉粥样硬化中的主要作用机制进行综述,为动脉粥样硬化预防和干预提供参考。Research has shown that occupational stress is closely related to the occurrence and progression of atheroscle⁃rosis,with immune dysregulation serving as a mediating factor.Occupational stress triggers immune dysregulation in the body,ultimately leading to atherosclerosis through mechanisms such as the activation of immune cells and inflammatory mediators,endothelial dysfunction,and lipid metabolism disorders.This article reviews the primary mechanisms by which immune dysregulation plays a role in atherosclerosis caused by occupational stress,providing the reference for the prevention and intervention of atherosclerosis.

关 键 词：动脉粥样硬化 职业紧张 免疫调节 炎症 

分 类 号：R543.5[医药卫生—心血管疾病] R392[医药卫生—内科学]