米索前列醇片与地诺前列酮栓用于足月引产临床效果比较  

Comparison of Effects of Misoprostol Vaginal Tablets and Dinoprostone Suppositories for Term Pregnancy in Inducing Labor

作　　者：杨丽中 徐洲 刘海霞 廖艳丽 卢也频 Yang Lizhong;Xu Zhou;Liu Haixia(Sichuan Jinxin Xinan Women&Children Hospital,Chengdu,Sichuan 610000,China)

机构地区：[1]四川锦欣西囡妇女儿童医院,四川成都610000

出　　处：《四川医学》2024年第11期1259-1262,共4页Sichuan Medical Journal

摘　　要：目的探讨米索前列醇片与地诺前列酮栓在足月引产中的临床效果和安全性。方法选取2021年6月至2023年2月我院收治的妊娠足月宫颈不成熟引产的孕妇,其中米索前列醇片(新剂型25μg)引产243例、地诺前列酮栓(10 mg)引产156例,阴道内放置药物;回顾性分析两组用药后宫颈成熟、分娩方式、分娩并发症等。结果两组用药后宫颈成熟度、分娩方式比较差异无统计学意义(P>0.05);放药24 h阴道分娩率、宫缩过频率地诺前列酮组明显高于米索前列醇阴道组(P<0.01),24~48 h阴道分娩率、加用缩宫素率米索前列醇组明显高于地诺前列酮组(P<0.01);产后出血量≥500 ml、阴道助产、急产、新生儿转儿科、羊水污染等分娩并发症两组比较差异无统计学意义(P>0.05)。结论米索前列醇片和地诺前列酮栓在足月促宫颈成熟效果、分娩方式、母婴安全性相当,米索前列醇作用相对缓和,需要加用缩宫素比率较高,但较少引起宫缩过频,可推广使用。Objective To study effects and safety of misoprostol vaginal tablets and dinoprostone suppositories for term pregnancy in inducing labor.Methods Term pregnant women with cervical immaturity and indications for labor induction in our hospital were selected and admitted between June 2021 to February 2023 in our hospital.Among them,243 cases were induced with misoprostol vaginal tablets(new dosage forms,25μg),156 cases were induced with dinoprostone suppositories(10 mg),intravaginal administration of drugs.The cervical maturity after drug administration,method of delivery and complications of delivery were compared retrospectively.Results The comparison of the cervical maturity after drug administration and method of delivery showed no statistical difference(P>0.05).Compared with two groups,dinoprostone suppositories group had a higher rate of the vaginal delivery at 24 h of drug administration and over frequent contractions than the misoprostol vaginal tablets group(P<0.01).The misoprostol vaginal tablets group had a higher rate of the vaginal delivery at 24~48 h of drug administration and additional using oxytocin than the dinoprostone suppositories group(P<0.01).The comparison of the complications of delivery such as postpartum hemorrhage≥500 ml,operative vaginal delivery,urgent production,the rate of neonatal transfer from obstetrics to pediatrics and amniotic fluid pollution showed no statistical difference(P>0.05).Conclusion Misoprostol vaginal tablets and dinoprostone suppositories are comparable in cervical ripening promotion at term pregnancy,method of delivery and the safety of maternal and infant.Misoprostol vaginal tablets has a relatively mild effect,and has a higher rate of additional using oxytocin,but is less likely to cause over frequent contractions,can be promoted for clinical using.

关 键 词：米索前列醇片 地诺前列酮栓 足月妊娠 引产 

分 类 号：R714.3[医药卫生—妇产科学]