糖尿病合并颈动脉斑块患者血脂、氧化性低密度脂蛋白水平及与氧化应激的关系  

Study on Lipid Levels,Oxidized Low-Density Lipoprotein Levels,and Their Relationship with Oxidative Stress in Patients with Diabetes Combined with Carotid Plaques

作　　者：吴一迪 禹香菊 张静 WU Yidi;YU Xiangju;ZHANG Jing(Department of Laboratory Medicine,Zhengzhou Ninth People's Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市第九人民医院检验科,河南郑州450000

出　　处：《临床研究》2024年第12期16-19,共4页Clinical Research

摘　　要：目的探讨糖尿病合并颈动脉斑块患者血脂、氧化性低密度脂蛋白水平及与氧化应激的关系。方法选取2021年10月至2023年10月郑州市第九人民医院收治的85例糖尿病患者(设为糖尿病组)和90例糖尿病合并颈动脉斑块患者(设为研究组)及同期在本院进行体检的80例健康体检者(设为对照组)的临床资料进行回顾性分析。检测三组研究对象血脂、氧化性低密度脂蛋白水平及与氧化应激指标并进行对比,采用Pearson软件分析研究组血脂、氧化性低密度脂蛋白水平及与氧化应激的关系。结果三组研究对象性别,平均年龄比较,差异无统计学意义(P>0.05),而研究组和糖尿病组抽烟率、酗酒率、高血压率均高于对照组,且研究组高血压率高于糖尿病组,差异有统计学意义(P<0.05)。研究组、糖尿病组患者血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、氧化性低密度脂蛋白胆固醇(ox-LDL-C)、ox-LDL-C/LDL-C、小而密低密度脂蛋白胆固醇(sdLDL-C)、ox-LDL-C/sdLDL-C、丙二醛(MDA)水平均高于对照组,差异有统计学意义(P<0.05),研究组患者甘油三酯(TG)、LDL-C、ox-LDL-C、ox-LDLC/LDL-C、sdLDL-C、ox-LDL-C/sdLDL-C、MDA水平均高于糖尿病组,差异有统计学意义(P<0.05),研究组和糖尿病组患者高密度脂蛋白胆固醇(HDL-C)、超氧化酶歧化酶(SOD)水平低于对照组,且研究组患者HDL-C、SOD水平低于糖尿病组,差异有统计学意义(P<0.05),糖尿病合并颈动脉斑块的独立危险因素为LDL-C、ox-LDL-C、高血压、sdLDL-C、MDA(P<0.05),HDL-C、SOD则为糖尿病合并颈动脉斑块的保护因素(P<0.05)。研究组和糖尿病组患者血清LDL-C、ox-LDL-C、ox-LDL-C/LDL-C、ox-LDL-C/sdLDL-C与SOD水平呈负相关;HDL-C与SOD水平呈正相关,而LDL-C、ox-LDL-C、ox-LDL-C/LDL-C、ox-LDL-C/sdLDL-C与MDA水平呈正相关,HDL-C与MDA呈负相关。结论糖尿病合并颈动脉斑块患者血脂、氧化性低密度脂蛋白水平和SOD呈负�Objective To explore the lipid levels,oxidized low-density lipoprotein(ox-LDL)levels,and their relationship with oxidative stress in patients with diabetes combined with carotid plaques.Methods A retrospective analysis was conducted on clinical data from 85 diabetes patients(designated as the diabetes group),90 patients with diabetes combined with carotid plaques(designated as the study group),and 80 healthy individuals undergoing physical examinations at the hospital during the same period(designated as the control group)from October 2021 to October 2023.The lipid levels,ox-LDL levels,and oxidative stress indicators were measured and compared among the three groups.Pearson software was used to analyze the relationship among lipid levels,ox-LDL levels,and oxidative stress in the study group.Results There were no statistically significant differences in gender and average age among the three groups(P>0.05).However,the smoking rate,alcohol abuse rate,and hypertension rate in both the study group and diabetes group were higher than those in the control group,with the study group having a higher hypertension rate than the diabetes group,showing statistically significant differences(P<0.05).The serum levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),oxidized low-density lipoprotein cholesterol(ox-LDL-C),ox-LDL-C/LDL-C ratio,small dense low-density lipoprotein cholesterol(sdLDL-C),ox-LDL-C/sdLDL-C ratio,and malondialdehyde(MDA)levels in the study group and diabetes group were significantly higher than those in the control group the difference was statistically significant(P<0.05).Additionally,levels of triglycerides(TG),LDL-C,ox-LDL-C,ox-LDL-C/LDL-C,sdLDL-C,ox-LDL-C/sdLDL-C,and MDA in the study group were higher than those in the diabetes group the difference was statistically significant(P<0.05).The levels of high-density lipoprotein cholesterol(HDL-C)and superoxide dismutase(SOD)were lower in both the study group and diabetes group compared to the control group,with the study group exhibiting

关 键 词：糖尿病 颈动脉斑块 氧化性低密度脂蛋白 氧化应激 血脂 

分 类 号：R587.1[医药卫生—内分泌]