来曲唑预防取卵术后卵巢过度刺激综合征的临床效果观察  

Clinical Observation of Letrozole in Preventing Ovarian Hyperstimulation Syndrome After Oocyte Retrieval

作　　者：岳燕[1] 邢晶晶 刘敏[1] 张富青[1] YUE Yan;XING Jingjing;LIU Min;ZHANG Fuqing(Department of Reproductive Genetics,Zhengzhou Maternal and Child Health Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市妇幼保健院生殖遗传科,河南郑州450000

出　　处：《临床研究》2024年第12期23-26,共4页Clinical Research

基　　金：河南省医学科技攻关计划项目(LHGJ20220880)。

摘　　要：目的探究取卵术后,应用来曲唑(LE)预防卵巢过度刺激综合征(OHSS)的价值。方法研究样本共计300例,选取于郑州市妇幼保健院生殖遗传科2022年5月至2024年3月期间,行体外受精-胚胎移植(IVF-ET)助孕治疗,均采用卵泡期长效长促排方案,且因OHSS高风险需全胚冷冻的不孕患者,依据用药方案将其分为试验组(n=150,取卵术后当日起连续口服LE 4 d,7.5 mg/qd),对照组(n=150,取卵术后不口服LE干预),采用前瞻性研究对取卵术后患者进行跟踪随访和评估,比较两组取卵术后第3 d、第5 d雌二醇(E_(2))、血常规、肝肾功能、凝血功能水平、双侧卵巢大小及胸腹腔积液情况以及OHSS发生率。结果取卵术前,两组临床效果指标比较,差异无统计学意义(P>0.05);取卵术后第3 d、第5 d试验组E_(2)、白细胞计数水平均显著低于对照组,差异均有统计学意义(P<0.05),取卵术后第3 d、第5 d两组肝肾功能及凝血功能指标方面比较,差异均无统计学意义(P>0.05);取卵术后第3 d、第5 d试验组彩超检测情况(卵巢最大长径、胸腹腔积液)均显著低于对照组,差异均有统计学意义(P<0.05);治疗后,试验组OHSS发生率低于对照组,差异具有统计学意义(P<0.05)。结论取卵术后应用LE预防OHSS,能够显著改善患者临床恢复指标,缓解双侧卵巢大小及胸腹腔积液情况,降低OHSS发生率,整体应用价值较为理想,具有临床应用意义。Objective To explore the value of letrozole(LE)in preventing ovarian hyperstimulation syndrome(OHSS)after oocyte retrieval.Methods A total of 300 patients were selected for this study from the Department of Reproductive Genetics at Zhengzhou Maternal and Child Health Hospital between May 2022 and March 2024.All patients underwent in vitro fertilization and embryo transfer(IVF-ET)treatment,employing a long protocol for controlled ovarian stimulation due to the high risk of OHSS,requiring full embryo cryopreservation.Based on the treatment regimen,patients were divided into two groups:the experimental group(n=150)received oral LE at a dose of 7.5 mg daily for 4 days starting from the day of oocyte retrieval,while the control group(n=150)did not receive LE.A prospective study design was used for follow-up and assessment of patients after oocyte retrieval,comparing estradiol(E_(2)),complete blood count,liver and kidney function,coagulation function levels,bilateral ovarian size,abdominal and chest effusion,and the incidence of OHSS on the 3rd and 5th days post-retrieval.Results There were no statistically significant differences in clinical indicators between the two groups before oocyte retrieval(P>0.05).On the 3rd and 5th days post-retrieval,E_(2)levels and white blood cell counts in the experimental group were significantly lower than those in the control group the difference was statistically significant(P<0.05).No significant differences were found between the two groups regarding liver and kidney function and coagulation function indicators on the 3rd and 5th days post-retrieval(P>0.05).Additionally,ultrasound measurements(maximum ovarian diameter and abdominal/chest effusion)on the 3rd and 5th days post-retrieval were significantly lower in the experimental group than those in the control group(P<0.05).The incidence of OHSS in the experimental group was also significantly lower than that in the control group after treatment(P<0.05).Conclusion The application of letrozole after oocyte retrieval for the preventi

关 键 词：来曲唑 取卵术 卵巢过度刺激综合征 临床效果 雌二醇 

分 类 号：R711.75[医药卫生—妇产科学]