中医辨证用药在PCOS不孕症患者促排中的应用  

Application of Traditional Chinese Medicine Syndrome Differentiation in Ovulation Induction for Infertility in PCOS Patients

作　　者：王秋菊 WANG Qiuju(Department of Traditional Chinese Medicine,Zhoukou Yongshan Hospital,Zhoukou Henan 461300,China)

机构地区：[1]河南省周口永善医院中医科,河南周口461300

出　　处：《临床研究》2024年第12期27-29,共3页Clinical Research

摘　　要：目的观察中医辨证用药在多囊卵巢综合征(PCOS)促排中的作用。方法回顾性分析河南省周口永善医院2014年8月至2020年8月收治的90例PCOS不孕症患者,统计其常规应用来曲唑联合促性腺激素(GN)促排下的门诊促排卵自然受孕周期,根据治疗方法,将患者分为中医辨证用药组、补肾健脾协方组及无中药应用组,比较三组GN用药情况、直径大于18 mm的卵泡数目情况及妊娠率情况。结果中药辨证用药组GN平均用量最少(约450 U),补肾健脾协方组用量其次(约675 U),无中药组用量最多(约825 U)。三组卵泡直径大于18 mm以上卵泡数目情况比较,差异无统计学意义(P>0.05)。三组妊娠率比较,差异有统计学意义(P<0.05)。其中中药辨证用药组妊娠率最高(44.00%),补肾健脾协方组其次(23.81%),无中药组最后(18.75%),中药辨证用药组与补肾健脾协方组组内妊娠率明显高于无中药组,差异有统计学意义(P<0.05)。结论来曲唑联合GN联合辨证用药可以提升患者妊娠率,减少GN用量。Objective To observe the role of traditional Chinese medicine syndrome differentiation in ovulation induction in patients with polycystic ovary syndrome(PCOS).Methods A retrospective analysis was conducted on 90 cases of PCOS infertility patients treated at Zhoukou Yongshan Hospital from August 2014 to August 2020.Statistics were gathered on the natural conception cycles of outpatient ovulation induction under the routine application of letrozole combined with gonadotropin(GN)stimulation.Based on treatment methods,patients were divided into the TCM syndrome differentiation group,the kidney-tonifying and spleen-strengthening formula group,and the non-TCM group.The study compared the three groups in terms of GN usage,the number of follicles with diameters greater than 18 mm,and pregnancy rates.Results The TCM syndrome differentiation group had the lowest average usage of GN at about 450 U,followed by the kidney-tonifying and spleen-strengthening formula group at about 675 U,and the non-TCM group with the highest at about 825 U.There was no statistically significant difference in the number of follicles greater than 18 mm in diameter among the three groups(P>0.05).However,pregnancy rates differed significantly among the groups(P<0.05),with the TCM syndrome differentiation group achieving the highest pregnancy rate(44.00%),followed by the kidney-tonifying and spleen-strengthening formula group(23.81%),and the non-TCM group(18.75%).The pregnancy rates in both the TCM syndrome differentiation group and the kidney-tonifying and spleen-strengthening formula group were significantly higher than those in the non-TCM group,with statistically significant differences(P<0.05).Conclusion Letrozole combined with GN and TCM syndrome differentiation can improve pregnancy rates and reduce GN usage.

关 键 词：多囊卵巢综合征 中医辨证 GN用量 妊娠率 

分 类 号：R711.75[医药卫生—妇产科学]