纳洛酮联合丙种球蛋白治疗小儿病毒性脑炎的效果分析  

Analysis of the Effects of Naloxone Combined with Immunoglobulin Therapy in Children with Viral Encephalitis

作　　者：尹翠 宋哲 张映雪 YIN Cui;SONG Zhe;ZHANG Yingxue(Department of Pediatric Neurology,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院儿童神经内科,河南南阳473000

出　　处：《临床研究》2024年第12期66-69,共4页Clinical Research

摘　　要：目的分析纳洛酮联合丙种球蛋白治疗小儿病毒性脑炎的效果。方法纳入2021年12月至2023年12月南阳市中心医院收治的78例病毒性脑炎患儿为研究样本,按照随机单双数抽签法划分组别,39例单数入对照组,予以常规治疗,另外39例双数入研究组,在常规治疗开展前提下进行纳洛酮+丙种球蛋白治疗。对比两组治疗有效率、症状体征消失时间、治疗前后脑脊液炎性因子指标[C反应蛋白(CRP)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)]及治疗前后血清神经元特异性烯醇化酶(NSE)水平。结果研究组治疗有效率(94.87%)显著高于对照组(74.36%),差异有统计学意义(P<0.05);研究组发热消失时间、惊厥消失时间、脑膜刺激征消失时间、意识障碍消失时间均显著短于对照组,差异有统计学意义(P<0.05);治疗前组间各炎症因子水平比较,差异无统计学意义(P>0.05),治疗后两组CRP、TNF-α、IL-6水平均显著低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗前两组NSE水平比较,差异无统计学意义(P>0.05),治疗后两组NSE水平均显著低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论纳洛酮联合丙种球蛋白治疗小儿病毒性脑炎,可加速症状体征消失,促进炎症消退与神经功能恢复,值得应用。Objective To analyze the effects of naloxone combined with immunoglobulin therapy in the treatment of children with viral encephalitis.Methods A total of 78 children diagnosed with viral encephalitis who were admitted to Nanyang Central Hospital from December 2021 to December 2023 were included in the study.Patients were randomly divided into two groups using odd-even number drawing:39 patients were assigned to the control group and received conventional treatment,while the other 39 patients in the study group received naloxone combined with immunoglobulin therapy in addition to standard treatment.The treatment efficacy rates,duration until symptom resolution,and levels of inflammatory factors in cerebrospinal fluid[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)]and serum neuron-specific enolase(NSE)before and after treatment were compared between the two groups.Results The treatment efficacy rate in the study group(94.87%)was significantly higher than that in the control group(74.36%),with a statistically significant difference(P<0.05).The duration until resolution of fever,seizures,meningeal irritation signs,and consciousness disturbances in the study group were all significantly shorter than those in the control group(P<0.05).There were no significant differences in the levels of inflammatory factors between the two groups before treatment(P>0.05).After treatment,levels of CRP,TNF-α,and IL-6 were significantly lower than before treatment in both groups,and the study group had significantly lower levels than the control group(P<0.05).Similarly,there were no significant differences in NSE levels between the two groups before treatment(P>0.05),but after treatment,NSE levels were significantly lower than before treatment in both groups,with the study group showing significantly lower levels than the control group(P<0.05).Conclusion The combined treatment of naloxone and immunoglobulin in children with viral encephalitis can accelerate the resolution of symptoms,promote the reducti

关 键 词：纳洛酮 丙种球蛋白 小儿病毒性脑炎 炎性因子 

分 类 号：R725.1[医药卫生—儿科]