基于HR-pQCT的绝经女性在体骨小梁局部特异性研究  

Regional variation of trabecular bone density,microstructure and stiffness at distal tibia postmenopausal women:an in-vivo HR-pQCT study

作　　者：杜娟 黄蒙恩 李思敏 SILBERSCHMIDT V V 苗军[3] 明东 DU Juan;HUANG Meng'en;LI Simin;SILBERSCHMIDT V V;MIAO Jun;MING Dong(Academy of Medical Engineering and Translational Medicine,Tianjin University,300072 Tianjin,China;Wolfson School of Mechanical,Electrical and Manufacturing Engineering,Loughborough University,LE113TU Leicestershire,UK;Second Department of Spine,Tianjin Hospital,300210 Tianjin,China)

机构地区：[1]天津大学医学工程与转化医学研究院,天津300072 [2]Wolfson School of Mechanical,Electrical and Manufacturing Engineering,Loughborough University,LE113TU Leicestershire [3]天津市天津医院脊柱二科,天津300210

出　　处：《应用力学学报》2024年第6期1411-1417,共7页Chinese Journal of Applied Mechanics

基　　金：天津市自然科学基金重点资助项目(No.20JCZDJC00800);中国博士后面上资助项目(No.2022M712363)。

摘　　要：提出绝经后女性骨小梁的体密度(volume bone mineral density,vBMD)、力学特性与组织形态计量参数在体分析方法,揭示其在不同解剖学区域的特异性分布规律,骨小梁组织结构与力学特点的局部相关关系。运用高分辨率外周定量断层扫描(high resolution peripheral quantitative computed tomographic,HR-pQCT),首次建立了骨密度区域映射方法和骨小梁与骨髓多材料有限元模型,在体分析了10名绝经后女性骨小梁在胫骨前、后、外、内侧4个解剖区域的骨密度分布与力学特点区域间特异性。运用统计学方法分析组织形态参数与刚度局部区域间的相关性。研究发现骨小梁力学特性、结构与密度在不同解剖学部位的差异具有显著性差异,最低(前侧)骨小梁的强度为最高(内侧)区域的29.11%(P<0.05)。并且发现胫骨前侧和后侧、内侧和外侧都表现出了显著的两两相关的关系。骨小梁与骨髓多材料有限元模型方法为在体分析骨小梁力学与材料特性提供了可能方法。骨组织结构存在区域间相关关系,对了解胫骨材料特点,预测胫骨骨折部位具有指导性意义。This study aimed to determine a spatial distribution of trabecular volume bone mineral density(vBMD),mechanical vBMD and morphological properties,and examine the contribution of regional variability of trabecular microarchitecture to mechanical competence.Four anatomic regions of trabecular bone-anterior,posterior,lateral,and medial-from ten postmenopausal women were studied.Region-specific trabecular parameters such as trabecular bone mineral density,volume fraction,trabecular thickness,trabecular number,trabecular surface area,trabecular separation,and finite element analysis of trabecular stiffness were determined based on in-vivo high resolution peripheral quantitative computed tomographic(HR-pQCT)images.The regional linear regression of morphological parameters and stiffness were calculated.Significant regional variation in trabecular stiffness of the human distal tibia was observed(P<0.05),with up to 29.11%differences between the lowest(anterior)and highest(medial)regions.It was also found that there was significant relationship between tibia anterior and posterior or between tibia medial and lateral.The finite element analysis of trabecular bone and bone marrow multiple materials provides possible methods for in-vivo analysis of the mechanical and material characteristics of trabecular bone.The evaluation of regional variations in mechanical competence and trabecular specifications may allow better understanding of fracture risks in addition to other contributing factors.

关 键 词：高分辨率外周定量断层扫描 在体 骨小梁 骨密度 有限元分析 

分 类 号：R318.01[医药卫生—生物医学工程]