耳内镜下脱细胞真皮基质修复鼓膜穿孔的临床疗效研究  

Effect Analysis of Acellular Dermal Matrix in Tympanic Membrane Repair Surgery under Ear Endoscopy

作　　者：李玉瑾[1] 张欣[1] 吕凌云[1] 李梦萧 金新[1] LI Yujin;ZHANG Xin;LV Lingyun;LI Mengxiao;JIN Xin(Department of Otolaryngology-Head and Neck Surgery,The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an,Jiangsu Province 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院耳鼻咽喉科,江苏淮安223300

出　　处：《吉林医药学院学报》2024年第6期423-425,共3页Journal of Jilin Medical University

基　　金：2023年度淮安市基础研究计划(联合专项)卫生健康类项目(HABL2023100)。

摘　　要：目的探讨脱细胞真皮基质(acellular dermal matrix,ADM)在耳内镜下鼓膜修补术中的临床疗效。方法选取2020年9月至2023年9月期间在南京医科大学附属淮安第一医院接受耳内镜下鼓膜修补术的54例患者作为研究对象,根据使用修补材料的不同,分为A组(28例)和B组(26例)。其中,A组使用ADM作为修补材料,B组则使用耳屏软骨-软骨膜。比较两组患者的并发症、鼓膜愈合情况及术后听阈改善情况。结果B组患者中有2例出现了耳屏畸形。术后3个月时,A组的鼓膜穿孔愈合率为92.86%,B组的愈合率为92.31%,两组间比较差异无统计学意义(P>0.05)。术后A组的平均气骨导差为(13.64±2.26)dB,B组为(14.15±2.62)dB,两组间比较差异无统计学意义(P>0.05)。结论ADM修复鼓膜穿孔疗效满意,可避免第二手术切口,减少手术损伤,值得临床应用。Objective To explore the clinical efficacy of decellularized dermal matrix(ADM)in tympanic membrane repair surgery.Methods 54 patients who underwent endoscopic tympanic membrane repair surgery in the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from September 2020 to September 2023 were selected,and they were divided into Group A(28 cases)and Group B(26 cases)based on the different repair materials.The patients in the Group A used acellular dermal matrix as the repair material,while the patients in Group B used tragus cartilage-perichondrium.The complications,tympanic membrane healing,and postoperative hearing threshold were compared between the two groups.Results Two patients in Group B developed tragus deformities.The healing rate of tympanic membrane perforation was 92.86%in Group A and 92.31%in Group B 3 months after operation,and there was no statistical difference between the two groups(P>0.05).The mean air-bone gap was(13.64±2.26)dB in Group A and(14.15±2.62)dB in Group B,and there was no significant difference between the two groups(P>0.05).Conclusion The therapeutic effect of ADM in repairing tympanic membrane perforation is satisfying,which can avoid a second surgical incision and reduce surgical damage.It is worth applying in clinical practice.

关 键 词：耳屏软骨-软骨膜 鼓膜修补 脱细胞真皮基质 

分 类 号：R764.9[医药卫生—耳鼻咽喉科]