复方中药提高子宫内膜容受性的研究进展  

Research Progress on Compound Chinese Medicine Improving Endometrial Receptivity

作　　者：杨美艳 李爽[1] 刘会玲[2] 潘晓燕[1] YANG Meiyan;LI Shuang;LIU Huiling;PAN Xiaoyan(Center for Reproductive Medicine,Jilin Medical University,Jilin City,Jilin Province 132013;Department of Obstetrics and Gynecology,Affiliated Hospital of Jilin Medical University,Jilin City,Jilin Province 132013,China)

机构地区：[1]吉林医药学院生殖医学研究中心,吉林吉林132013 [2]吉林医药学院附属医院妇产科,吉林吉林132013

出　　处：《吉林医药学院学报》2024年第6期449-453,共5页Journal of Jilin Medical University

基　　金：吉林省发展和改革委员会产业技术研究与开发项目(2023C027-8);吉林省科技发展计划项目(YDZJ202301ZYTS178)。

摘　　要：良好的子宫内膜状态是成功妊娠的关键。疾病、辅助生殖技术中的促排卵处理和堕胎等因素会损伤子宫内膜发育,破坏植入期子宫内膜容受性,影响胚胎对子宫内膜的识别和植入。复方中药通过补肾、提气和活血等功效可全面、协调促进子宫内膜发育,提高子宫内膜容受性,在临床被广泛用于治疗女性不孕不育。本文从子宫内膜胞饮突形成、血管生成、胚胎植入期激素分泌和子宫内膜容受性标志性分子表达等方面阐述复方中药对提高子宫内膜容受性的作用和机制,为临床治疗子宫内膜损伤、提高女性受孕率提供新的思路和理论依据。Good endometrial condition is the key to a successful pregnancy.Many factors,such as diseases,ovulation induction in assisted reproductive technology and abortion,can damage endometrial development,destroy endometrial receptivity during implantation,and affect embryo recognition and implantation.Compound Chinese medicine can promote endometrial development and improve endometrial receptivity through the functions of tonifying kidney,lifting qi and promoting blood circulation,and is widely used in clinical treatment of female infertility.In this paper,the effects and mechanisms of compound Chinese medicine on improving endometrial receptivity were described from the aspects of endometrial pinopode formation,endometrial angiogenesis,estrogen secretion during implantation,expression of endometrial receptivity landmark molecules and endometrial decidualization,which provided new ideas and theoretical basis for clinical treatment of endometrial injury,improvement of endometrial receptivity and female pregnancy rate.

关 键 词：复方中药 子宫内膜容受性 胞饮突 血管生成 

分 类 号：R285[医药卫生—中药学]