乙酸铜催化甲亚胺亚胺的环加成反应  

Cupric Acetate-Catalyzed Cycloaddition Reaction of Azomethine Imines

作　　者：刘彦韬 李爱雪 张芳 张慧东 LIU Yantao;LI Aixue;ZHANG Fang;ZHANG Huidong(Eastern Liaoning University,Dandong Liaoning 118003,China)

机构地区：[1]辽东学院化工与机械学院,辽宁丹东118003

出　　处：《辽宁化工》2024年第11期1712-1716,共5页Liaoning Chemical Industry

基　　金：辽东学院博士科研启动基金项目(项目编号:2019BS013)。

摘　　要：吡唑啉酮杂环在生物和材料领域有着重要的应用。采用乙酸铜作为催化剂,邻氨基酚作为配体,二氯甲烷作为溶剂,成功实现了甲亚胺亚胺化合物和端炔的1,3-偶极环加成反应。该反应产率高,并且速度快、选择性高、条件温和、操作简单,对水和空气不敏感,而且催化剂和配体都廉价易得,性质稳定。相较于已有文献,实验所采用的方法使用室温敞开体系下的温和条件,无需手套箱操作和隔绝氧气,同时大大提高了反应速率。Pyrazolinone heterocycles have significant applications in biological and material fields.In this study,the 1,3-dipolar cycloaddition reaction of azomethine imine compounds and terminal alkynes was achieved by using cupric acetate as catalyst,2-aminophenol as ligand,and dichloromethane as solvent.The reaction showed high productivity,speed,selectivity,condition mildness,simplicity of operation,and insensitivity to water and air.The catalyst and ligand were stable and easily accessible.Compared to existing literatures,the method adopted in this paper used mild conditions in an open system at room temperature,without glove box operation and oxygen isolation,and at the same time the reaction rate was greatly improved,which complements and develops the existing conditions.

关 键 词：乙酸铜 邻氨基酚 环加成反应 甲亚胺亚胺 

分 类 号：O621.256.7[理学—有机化学]