检测活性氧近红外荧光探针研究进展  

Research Progress in Near-Infrared Fluorescence Probes for Detecting Reactive Oxygen Species

作　　者：肖彬 王春梅 韩正浩 XIAO Bin;WANG Chunmei;HAN Zhenghao(College of Chemistry&Chemical Engineering,Yunnan Normal University,Kunming Yunnan 650500,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《辽宁化工》2024年第11期1761-1763,共3页Liaoning Chemical Industry

摘　　要：活性氧(ROS)在化学、生物学和医学上引起了许多研究人员的注意,它在许多关键的生理过程中起着重要的作用,活性氧在体内的过量产生和积累会损害一些生物分子,直接或间接导致多种疾病,因此它们被认为与各种病理条件有关。探究活性氧在体内的具体致病机理,并且在了解该致病机理的基础上研发相关药物,变得尤为重要。检测活性氧的近红外荧光探针是一个新的有前途的工具,可以无创的情况下检测体内细胞系统中目标生物分子的空间和时间信息,并在此基础上提供一个较好的治疗方案。Reactive oxygen species(ROS)have attracted the attention of many researchers in chemistry,biology and medicine,it plays important role in many key physiological processes,the excessive production and accumulation of ROS in the body can damage some biomolecules,directly or indirectly cause a variety of diseases,so they are considered to be related to various pathological conditions.it is important to explore the specific pathogenic mechanism of reactive oxygen species in the body to develop related drugs based on the understanding of this pathogenic mechanism.Near-infrared fluorescent probes for the detection of reactive oxygen species is a promising tool for non-invasive detection of spatial and temporal information of target biomolecules in vivo cellular systems,providing a more promising treatment based on this.

关 键 词：活性氧 近红外 荧光探针 生物成像 

分 类 号：O657.3[理学—分析化学]