我国妊娠期妇女血小板抗体阳性率Meta分析  

Meta Analysis of Incidence of Platelet Antibody in Pregnant Women in China

作　　者：李欣 杨俊鸿[2] LI Xin;YANG Junhong(Department of Clinical Laboratory,the First Affiliated Hospital of Army Medical University,Chongqing 400038;Chongqing Blood Center,Chongqing 400052)

机构地区：[1]陆军军医大学第一附属医院检验科,重庆400038 [2]重庆市血液中心,重庆400052

出　　处：《临床输血与检验》2024年第6期805-811,共7页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：重庆市科卫联合青年基金(No.2022QNXM056)资助。

摘　　要：目的系统分析我国妊娠期妇女血小板抗体阳性率及其影响因素。方法检索数据库PubMed、CNKI、EMbase、WanFang Data和VIP建库至2024年3月有关中国妊娠期妇女血小板抗体检测的研究文献。文献筛选和资料提取后,进行Meta分析。结果最终纳入24篇文献,共计41079名妊娠期妇女,其中2917名血小板抗体为阳性。妊娠期妇女总血小板抗体阳性率为8.05%。南方地区妊娠期妇女总血小板抗体阳性率为7.14%,低于北方的11.93%(P<0.01)。有妊娠史的妊娠期妇女血小板抗体阳性率为14.13%,高于无妊娠史的3.15%(P<0.01)。1次、2次和≥3次妊娠的妊娠期妇女血小板抗体阳性率分别为3.52%、8.47%和15.18,有明显统计学意义(P<0.01)。孕妇不同分娩方式经阴道产和剖宫产血小板抗体阳性率分别为10.10%和8.49%(P>0.05)。A型、B型、O型和AB型妊娠期妇女血小板抗体阳性率分别为8.86%、7.25%、6.38%和5.55%(P>0.05)。结论我国妊娠期妇女血小板阳性率与地域、妊娠史和妊娠次数具有相关性,未发现与不同分娩方式以及ABO血型之间的相关性。Objective To evaluate the incidence of platelet antibodies in pregnant women and its influencing factors.Methods The databases PubMed,CNKI,EMbase,WanFang Data and VIP were searched for studies on platelet antibodies detection in pregnant women in China from the establishment of the database to March 2024.Meta-analysis was performed after literature screening and data extraction.Results Twenty-four studies totaling 41079 pregnant women were finally included,of which 2917 were positive for platelet antibody.The total platelet antibody positive rate in pregnant women was 8.05%.The total platelet antibody positive rate was 7.14%in the southern region,lower than 11.93%in the northern region(P<0.01).The positive rate of pregnant women with a history of pregnancy was 14.13%,higher than that of 3.15%in those without pregnancy history(P<0.01).The positive rates of platelet antibodies in pregnant women with 1,2 and≥3 or more pregnancies were 3.52%,8.47%and 15.18,respectively,with statistically significant differences(P<0.01).The positive rates of platelet antibody among pregnant women with different modes of delivery were 10.10%and 8.49%for transvaginal and cesarean deliveries,respectively(P>0.05).The positive rates of platelet antibody in women with type A,B,O and AB were 8.86%,7.25%,6.38%and 5.55%,respectively(P>0.05).Conclusion The positive rate of platelet antibodies in Chinese pregnant women is correlated with region,pregnancy history and number of pregnancies,but not with delivery modes or ABO blood types.

关 键 词：孕妇 血小板抗体 META分析 

分 类 号：R457[医药卫生—治疗学]