mTOR通路在调控造血干细胞自我更新和分化中的研究进展  

Research Progress of mTOR Pathway in Regulating Self-renewal and Differentiation of Hematopoietic Stem Cells

作　　者：王嘉琪 肖军 李翠莹 WANG Jiaqi;XIAO Jun;LI Cuiying(Graduate School of Hebei North University,Zhangjiakou,Hebei Province 075000;Department of Blood Transfusion,Air Force Medical Center,Beijing 100142)

机构地区：[1]河北北方学院,河北张家口075000 [2]空军军医大学空军特色医学中心输血科,北京100142

出　　处：《临床输血与检验》2024年第6期818-824,共7页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：空军军医大学效能提升项目(No.2021HKYX15);空军特色医学中心青年人才项目(No.22BJQN009)资助。

摘　　要：哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝/苏氨酸蛋白激酶,在调节细胞的生长、增殖中起着重要的作用。mTOR复合体通过磷酸化激活下游底物S6K1、4E-BP等调节细胞生长、增殖、蛋白质代谢等等,同样mTOR信号通路在造血系统中也发挥重要作用,其整合多种信号对造血干细胞的静止、自我更新和多向分化三个过程起调节作用,本文系统介绍相关信号分子及蛋白如何通过影响mTOR信号通路并进一步影响造血干细胞发挥功能。The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that plays an important role in regulating cell growth,proliferation.The mTOR complex regulates cell growth,proliferation,protein metabolism by phosphorylating and activating downstream substrates such as S6K1,4E-BP,etc.The mTOR signalling pathway similarly plays an important role in the haematopoietic system,integrating multiple signals to regulate the three processes of haematopoietic stem cell quiescence,self-renewal and multidirectional differentiation.This article systematically describes how relevant signalling molecules and proteins affect the mTOR signalling pathway and further influence haematopoietic stem cell function.

关 键 词：造血干细胞 MTOR信号通路 造血分化 自我更新 恶性造血 

分 类 号：R457[医药卫生—治疗学]