红细胞免疫相关表面抗原及其功能  

Immune-related Surface Antigens and Functional Roles of Red Blood Cells

作　　者：齐畅 孟祥红[1] QI Chang;MENG Xianghong(Department of Blood Transfusion Medicine,8th Medical Center of PLA General Hospital,Beijing 100091;2Medical College of Basic Medicine,Jiamusi University,Jiamusi,Heilongjiang 154007)

机构地区：[1]解放军总医院第八医学中心输血医学科,北京100091 [2]佳木斯大学基础医学院,黑龙江佳木斯154007

出　　处：《临床输血与检验》2024年第6期855-859,共5页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：首都临床特色应用研究与成果推广项目(No.Z161100000516180)资助。

摘　　要：近年来,对红细胞免疫物质的研究结果表明,红细胞不仅是运氧的主要载体,同时也作为固有免疫细胞发挥多种免疫和调节功能。红细胞可通过增强免疫黏附、促进吞噬作用、调节补体活性、清除循环免疫复合物等机制执行免疫调控功能,其表面的免疫物质如TOLL受体9、补体受体1、CD58等可作为桥梁参与维持机体免疫平衡。探索具有免疫特性的红细胞及其细胞因子在机体发育和疾病发生发展中的作用具有重要临床意义。In recent years,research on immune substances in red blood cells has shown that red blood cells are not only the main carrier of oxygen transportation,but also play a variety of immune and regulatory functions as innate immune cells.These cells are capable of recognizing and adhering to antigens,fostering phagocytosis,engaing with complement system,and eliminating circulating immune complexes.Immune substances on its surface,such as Toll-like receptor 9(TLR9),complement receptor 1 and CD58,can act as bridges to maintain the immune balance of the body.Exploring the role of red blood cells with immune characteristics and their cytokines in the development and progression of diseases has important clinical significance.

关 键 词：红细胞 免疫 细胞因子 

分 类 号：R392[医药卫生—免疫学]