基于路易斯酸催化炔丙醇和2-烯基苯胺串联环化反应的制药工程综合创新实验  

Comprehensive Innovative Experiment of Pharmaceutical Engineering Based on Lewis Acid Catalyzed Cascade Cyclization of Propargyl Alcohols and 2-alkenyl Anilines

作　　者：韩亚平 吴云鑫 刘庆辉 HAN Yaping;WU Yunxin;LIU Qinghui(School of Chemical Engineering and Technology Hebei University of Technology,Tianjin 300130,China)

机构地区：[1]河北工业大学化工学院,天津300130

出　　处：《广州化工》2024年第23期204-208,共5页GuangZhou Chemical Industry

摘　　要：以最新的科研成果为基础设计了一个针对制药工程专业本科生的综合创新实验,研究了路易斯酸催化炔丙醇和2-烯基苯胺[4+2]环加成生成喹啉类化合物的反应,通过对催化剂、添加剂、溶剂、反应时间、反应温度等条件的考察,从而提高反应收率。在最优反应条件下考察带有不同取代基的炔丙醇和2-烯基苯胺的底物适用范围。该实验不仅可以提高学生的基本实验操作技能,加深对有机化学和药物合成的机理,同时能够培养学生的团队意识和创新精神。A comprehensive innovation experiment was designed for undergraduates majoring in Pharmaceutical Engineering on the basis of the latest scientific research results.The Lewis acid catalyzed[4+2]annulation reaction of propargylic alcohols with 2-vinylanilines for the assembly of quinoline skeletons was investigated.With the purpose of increasing the yield of this protocol,a series of reaction factors including catalyst,additive,solvent,reaction time and reaction temperature were investigated.The generalizability of the tandem annulation was explored by employing propargylic alcohols with 2-vinylanilines bearing various substituent groups under optimal reaction conditions.The undergraduate could not only improve their basic experimental operation skills,deepen their understanding of the organic chemistry and drug synthesis,but also cultivate their team consciousness,and innovative spirit through this comprehensive innovation experiment.

关 键 词：综合创新实验 路易斯酸催化 炔丙醇 2-烯基苯胺 喹啉类化合物 

分 类 号：G642.0[文化科学—高等教育学]