Integrated Eco-Health approach significantly reduces helminth infections in endemic Khong islands with emphasis on Schistosoma mekongi  

作　　者：Somphou Sayasone Youthanavanh Vonghachack Shang Xia Shan Lv Xiao-Nong Zhou Peter Odermatt 

机构地区：[1]Lao Tropical and Public Health Institute,Ministry of Health,Vientiane Capital,Lao PDR [2]Faculty of Basic Sciences,University of Health Sciences,Vientiane Capital,Lao PDR [3]National Institute of Parasitic Diseases at China CDC(Chinese Center for Tropical Diseases Research),NHC Key Laboratory of Parasite and Vector Biology,WHO Collaborating Centre for Tropical Diseases,Shanghai 200025,PR China [4]Department of Public Health and Epidemiology,Swiss Tropical and Public Health Institute,Allschwil,Switzerland [5]University of Basel,Basel,Switzerland

出　　处：《Infectious Diseases of Poverty》2024年第4期64-78,共15页贫困所致传染病（英文）

基　　金：This intervention study was funded by the International Development Research Centre;Foreign Affairs,Trade and Development Canada(through the Global Health Research Initiative),the Australian Agency for International Development for funding support,under funding number 105509-027;the International Joint Laboratory on Tropical Diseases Control in Greater Mekong Subregion from Shanghai Municipality Government(No.21410750200).

摘　　要：Background Helminth infections, includingOpisthorchis viverrini, hookworm, andTrichuris trichiura, are prevalent in Khong district, Champasack province, southern Lao People’s Democratic Republic (PDR). Schistosomiasis caused bySchistosoma mekongi is of public health concern on the islands of the Khong district. This study aimed to assess the impact of an Eco-Health/One-Health approach in combination with mass drug administration (MDA) to reduce these helminth infections.Methods We conducted a community intervention using a stepped-wedge trial approach on two endemic islands (Donsom and Donkhone) of the Khong district, Champasack province, Lao PDR, between April 2012 and March 2013. In each study village, 30–40 households were randomly selected. All members of selected households, who were at home during the study period were invited to participate in the study. A baseline study was conducted to assess helminth infections, knowledge attitudes and practices towardSchistosoma mekongi infection, behavior of open defecation and availability of latrine at home. After the baseline (T0), the Eco-Health/One-Health approach was implemented on Donsom (intervention) and Donkhone island (control). An assessment was conducted in 2014 (T1), one year after the completion of intervention implementation, to assess the short-term impact of the Eco-Health/One-Health approach on helminth infections and compare intervention and control islands. Later in 2015, the Eco-Health/One-Health approach was implemented on control island (Donkhone). After the implementation of intervention, the parasitological assessments were conducted annually in humans in 2015 (T2), in 2016 (T3) and in 2017 (T4), and in dogs in 2017 (T4) to evaluate the long-term impact of the intervention on helminth infections. Frequency was used to describe the prevalence of helminth infections. Logistic regression was applied to associate the KAP (knowledge, attitudes, and practices and open defecation behavior) and the reduction of helminth infections between interve

关 键 词：Schistosoma mekongi Opisthorchis viverrini Soil-transmitted helminth Parasite control Water Sanitation and hygiene Eco-Health/One-Health Lao PDR 

分 类 号：R532.21[医药卫生—内科学] R184[医药卫生—临床医学]