CCDC181 is required for proper spermiogenesis in mice  

作　　者：Xirui Zi Qingchao Li Yue Lu Qian Lyu Heng Guo Xiaoqian Meng Jun Zhou Huijie Zhao 

机构地区：[1]Center for Cell Structure and Function,Shandong Provincial Key Laboratory of Animal Resistance Biology,Collaborative Innovation Center of Cell Biology in Universities of Shandong,College of Life Sciences,Shandong Normal University,Jinan,Shandong 250014,China [2]State Key Laboratory of Medicinal Chemical Biology,Haihe Laboratory of Cell Ecosystem,College of Life Sciences,Nankai University,Tianjin 300071,China

出　　处：《Journal of Genetics and Genomics》2024年第11期1327-1330,共4页遗传学报（英文版）

基　　金：supported by National Natural Science Foundation of China(32270807 and 31900538);Shandong Natural Science Foundation(2022HWYQ-075 and tsqn202211109)。

摘　　要：Cilia are hair-like cellular projections essential for development and homeostasis,which can be grouped into either immotile or motile cilia based on their motility.In vertebrates,motile cilia that line the brain ventricles,respiratory tracts,and reproductive tracts exist as multiple cilia and beat in a coordinated fashion to generate a directional fluid flow across the epithelial surfaces(Lyu et al.,2024).In contrast,sperm cells have a single flagellum that shares a similar axoneme arrangement but possesses unique accessory structures,including the mitochondrial sheath,the fibrous sheath,and the outer dense fibers(Linck et al.,2016).Some ciliary proteins display distinct cellular distributions in multiple motile cilia and sperm flagella.For instance,outer dense fiber protein 2(ODF2)associates with basal bodies in tracheal motile cilia but is abundant in sperm flagella(Zhao et al.,2021;Zhu et al.,2022).These differences potentially grant sperm flagella distinctive properties.

关 键 词：outer arrangement fibers 

分 类 号：Q954.43[生物学—动物学]