COL:a method for identifying putatively functional circular RNAs  

作　　者：Zheng Li Bandhan Sarker Fengyu Zhao Tianjiao Zhou Jianzhi Zhang Chuan Xu 

机构地区：[1]Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Ministry of Education,Shanghai Jiao Tong University,Shanghai 200240,China [2]Department of Statistics,George Washington University,Washington,DC 20052,USA [3]Department of Otorhinolaryngology Head and Neck Surgery,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China [4]Department of Ecology and Evolutionary Biology,University of Michigan,Ann Arbor,MI 48109,USA

出　　处：《Journal of Genetics and Genomics》2024年第11期1338-1341,共4页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32270704,32100518 and 32472630);National Science and Technology Innovation 2030(2022ZD0214400);Engineering Shanghai Jiao Tong University(YG2022QN084);the U.S.National Institutes of Health(R35GM139484 to J.Z.)。

摘　　要：Circular RNAs(circRNAs)are a class of endogenous,singlestranded,covalently closed,mostly non-coding RNAs that are produced by back-splicing that links a downstream splice-donor site with an upstream splice-acceptor site(Chen,2016;Kristensen et al.,2019).CircRNAs have been reported to have important regulatory functions,such as acting as miRNA(Hansen et al.,2013;Memczak et al.,2013)or protein(Ashwal-Fluss et al.,2014)sponge to regulate gene expression,acting as scaffolds to mediate the formation of complexes(Du et al.,2016),and being translated into small functional peptides(Pamudurti et al.,2017).Notwithstanding,of millions of known circRNAs,those with demonstrated functions are a tiny fraction.

关 键 词：ENDOGENOUS FUNCTIONAL 

分 类 号：Q503[生物学—生物化学]