外泌体在成血管成骨偶联中作用的研究  

Progress in the role of exosomes in osteogenic coupling

作　　者：谢庆晟 于海洋 马涛 汪海燕 王泽鑫 郭强强 田杰祥 XIE Qingsheng;YU Haiyang;MA Tao;WANG Haiyan;WANG Zexin;GUO Qiangqiang;TIAN Jiexiang(School of Clinical Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Gaolan Hospital of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730000 [3]皋兰县中医医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2024年第12期1810-1814,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81960832);甘肃省中医药管理局常规课题(GZKP-2020-31;GZKP-2021-17);甘肃省科技厅自然科学基金(24JRRA554;21JR11RA161);兰州市科技发展指导性计划(2023-2D-202)。

摘　　要：外泌体(exosomes, EXO)是细胞分泌的一种特殊的囊泡,可以充当信使的作用,在细胞间传递信息分子,是成血管成骨偶联过程中的重要角色。外泌体可以通过本身及包含的各种因子如微小RNA、信号转导因子等与细胞相互作用,同时调节血管的生成以及骨再生,进而调控成血管成骨偶联的过程。目前研究中的外泌体大多来自于间充质干细胞、肿瘤细胞、巨噬细胞、内皮祖细胞等,在治疗血管相关骨疾病方面有很大的潜力。本文收集查阅近年来国内外发表的有关的文献,对外泌体影响成血管成骨偶联作用的相关研究进行综述分析,以期后续为外泌体与成血管成骨偶联作用的研究提供借鉴,为寻找治疗血管相关骨疾病的新靶点提供思路。Exosomes are a specialized vesicle secreted by cells that can transmit information molecules from the cells.Exosomes act as messengers in cell-to-cell signal transmission and play an important role in angiogenic coupling.Exosomes interact with cells through itself or self-contained various factors such as microRNA and signal transducer and activator of transcription,regulate the generation of blood vessels and bone regeneration,and then regulate the process of osteogenic coupling.Current research of exosomes is mostly from mesenchymal stem cells,tumor cells,macrophages,endothelial progenitor cells,etc.It has great potential in the treatment of vascular-related bone diseases.The recent domestic and foreign related literature on the role of exosomes in angiogenesis are widely reviewed and summarized in this note.We hope to provide reference for the subsequent studies on the coupling effect of exosomes and angiogenesis,and to provide ideas for finding new targets for the treatment of vascular-related bone diseases.

关 键 词：外泌体 血管生成 骨生成 

分 类 号：R68[医药卫生—骨科学]