从骨微结构角度探寻骨质疏松症的病情演变  

To explore the progress of diagnosis and treatment of osteoporosis from the perspective of bone microstructure

作　　者：胡晓帆 王宏宇 孙凡 胡咏新[2] HU Xiaofan;WANG Hongyu;SUN Fan;HU Yongxin(Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China;Department of Endocrinology,Affiliated Hospital of Integrated Traditional Chinese and WesternMedicine,Nanjing University of Traditional Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京中医药大学附属中西医结合医院内分泌科,江苏南京210028

出　　处：《中国骨质疏松杂志》2024年第12期1838-1841,共4页Chinese Journal of Osteoporosis

基　　金：江苏省中医药管理局科技项目(MS2021023);南京中医药大学自然科学基金项目(XZR2023011);南京市中医药传承创新发展示范试点资助项目(NJCC-ZJ-202349)。

摘　　要：骨质疏松防治是目前研究热点,现有治疗更多关注成骨和破骨细胞功能,而骨微结构损伤会导致骨强度降低,在骨质疏松发病中同样也起着重要作用。在骨微观架构中,骨小梁是承受复合力学的主要结构,而骨皮质主要维持力学改变的适应能力,两者在骨质疏松进程中表现不一,对常规抗骨质疏松治疗的药物反应也有所差异。该文将从骨微结构损伤方面探寻骨质疏松症的病情演变。The prevention and treatment of osteoporosis is currently a research hotspot,and the existing treatments pay more attention to the function ofosteoblasts and osteoclasts,while the damage of bone microstructure will lead to the reduction of bone strength,which also plays an important role in the pathogenesis of osteoporosis.In the microstructure of bone,trabecula is the main structure to withstand complex mechanics,while cortical bone mainly maintains the ability to adapt to mechanical changes.The two have different performance in the process of osteoporosis and have different drug responses to conventional anti-osteoporosis therapy.In this paper,we will explore the progress of diagnosis and treatment of osteoporosis from the perspective of bone microstructure.

关 键 词：骨质疏松症 骨皮质 骨小梁 

分 类 号：R589.5[医药卫生—内分泌]