从“肾-脑-骨”轴探讨PMOP与焦虑的相关性  

A review on the correlation between PMOP and anxiety from the"kidney brain bone"axis

作　　者：叶佰盛 李威 黄振 黄海 丰杰 陈琪 史晓林 YE Baisheng;LI Wei;HUANG Zhen;HUANG Hai;FENG Jie;CHEN Qi;SHI Xiaolin(The Second Clinical Medical School,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China;The Second Affiliated Hospital of Zhejiang University of traditional Chinese Medicine,Hangzhou 310005,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江中医药大学附属第二医院,浙江杭州310005

出　　处：《中国骨质疏松杂志》2024年第12期1854-1858,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82074183);浙江省自然科学基金(LZ22H270002);浙江省中医药科技计划中医药现代化专项基金(2020ZX009)。

摘　　要：目的根据“肾-脑-骨”轴理论,探寻绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)与焦虑状态的共同病机,以期为PMOP的防治构建新框架。方法通过检索中国知网、PubMed等数据库中关于“肾-脑-骨”轴理论以及PMOP、焦虑状态的相关文献与研究,深入探讨两者的关联。结果“肾-脑-骨”轴整合了中医学“肾、脑、骨”相关理论,概述3者间存在联系,而激素与神经肽则是联系3者的重要递质,而且能够从多层次参与骨稳态以及焦虑情绪的调节。结论“肾-脑-骨”轴理论揭示了PMOP与焦虑状态存在的共同病机,将“肾主骨”、“肾藏志”和神经肽调节领域3者相结合,为PMOP的防治提供新思路。Objective Based on the“kidney brain bone”axis theory,this study aims to explore the common pathogenesis of postmenopausal osteoporosis(PMOP)and anxiety state,in order to provide new ideas for PMOP.Methods By searching relevant literature and research on the“kidney brain bone”axis theory,PMOP,and anxiety state in databases such as CNKI and PubMed,we aim to explore the correlation between the two in depth.Results The“kidney brain bone”axis integrates the relevant theories of“kidney,brain,and bone”in traditional Chinese medicine,summarizing the connections between the three.Hormones and neuropeptides are important neurotransmitters that connect the three,and can participate in the regulation of bone homeostasis and anxiety from multiple levels and dimensions.Conclusion The theory of the“kidney brain bone”axis reveals the common pathogenesis between PMOP and anxiety state,combining“kidney governing bone”,“kidney storing consciousness”,and neuropeptide regulation,providing new ideas for PMOP.

关 键 词：“肾-脑-骨”轴 绝经后骨质疏松症 焦虑 

分 类 号：R274.9[医药卫生—中西医结合]