骨形态发生蛋白ⅠA型受体在骨代谢调控中的研究进展  

Research advances on BMPRⅠ A in bone metabolism regulation

作　　者：庞永杰 高玉海[1] 魏振龙 武艺[1] 安梓栋 王立强 陈克明[1] 高玉海 PANG Yongjie;GAO Yuhai;WEI Zhenlong;WU Yi;AN Zidong;WANG Liqiang;CHEN Keming(Basic Medicial Laboratory,the 940th Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army,Gansu Key Laboratory of Stem Cells and Genetic Drugs,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

出　　处：《中国骨质疏松杂志》2024年第12期1867-1872,共6页Chinese Journal of Osteoporosis

基　　金：军队后勤自主科研项目(2023HQZZ-07);联勤保障部队第940医院G计划人才项目(2024-G3-10);甘肃省自然科学基金(22JR11RA013);兰州市科技计划项目(2023-1-8)。

摘　　要：骨形态发生蛋白(BMPs)是平衡成骨细胞与破骨细胞分化,促进骨形成的关键因素,在全身多个器官组织中发挥重要作用。BMPs家族抑制或促进骨代谢相关疾病的信号通路,调控骨发育、重塑,作为BMP信号通路中关键信号分子的Ⅰ型受体,骨形态发生蛋白ⅠA型受体(BMPRⅠA)的缺失与否对整个BMP信号通路有着显著影响。本文综述BMPRⅠA在骨代谢调控中的研究进展,为后续BMPRⅠA和骨代谢的研究提供参考。Bone morphogenetic proteins(BMPs)play an important role in many organs and tissues of the whole body,which are the key factors to balance the differentiation of osteoblasts and osteoclasts and promote bone formation.BMPs family inhibits or promotes the signaling pathways of bone metabolism-related diseases,and regulates bone development and remodeling.As a key signaling molecule in BMP signaling pathway,the absence of bone morphogenetic protein type IA receptor(BMPRIA)has a significant impact on the entire BMP signaling pathway.This paper reviews the progress of BMPRⅠA in the regulation of bone metabolism,and provides reference for the subsequent study of BMPRⅠA and bone metabolism.

关 键 词：BMP BMPRⅠA 骨代谢 骨折 骨质疏松 

分 类 号：R336[医药卫生—人体生理学]