线粒体质量控制在COPD中的作用及治疗进展  

The mechanism and therapeutic progress of mitochondrial quality control(MQC)in COPD

作　　者：何光亮 王丹心[2] 刘磊 叶敏 HE Guangliang;WANG Danxin;LIU Lei;YE Min(Hainan Vocational University of Science and Technology,Haikou 571126,China;The First Affiliated Hospital of Hainan MedicalUniversity,Haikou 570102,China;Hainan Medical University,Haikou 570100,China;He jiang Hospital of Southwest MedicalUniversity,Luzhou 646200,China;Hejiang Traditional Chinese Medicine Hospital,Luzhou 646200,China)

机构地区：[1]海南科技职业大学,海南海口571126 [2]海南医学院第一附属医院,海南海口570102 [3]海南医科大学,海南海口570100 [4]西南医科大学附属医院合江医院,四川泸州646200 [5]合江县中医医院,四川泸州646200

出　　处：《海南医学院学报》2024年第23期1833-1840,共8页Journal of Hainan Medical University

基　　金：海南省自然科学基金资助项目(822RC833);海南省高等学校科学研究项目(Hnky2021ZD-15)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种全球常见疾病之一,其发病机制复杂,至今仍未完全明确,目前的治疗手段仍有局限。线粒体质量控制(MQC)是指受损或老化的线粒体被选择性地去除,新线粒体的产生,涉及线粒体的有丝分裂、线粒体动力学、生物发生等。越来越多的证据表明,线粒体质量控制失衡在COPD中具有重要的作用。现就MQC在COPD中的作用进行综述,并总结了COPD线粒体相关治疗进展,以期为COPD治疗新策略提供参考和借鉴。Chronic obstructive pulmonary disease(COPD)is one of the common diseases worldwide,with a complex patho-genesis that is still not fully understood,andcurrent treatment methods still have limitations.Mitochondrial quality control(MQC)mainly refers to the selective removal of damaged or aged mitochondria and the generation of new mitochondria,involving mito-chondrial biogenesis,mitochondrial dynamics,mitosis,etc.More and more evidence suggests that mitochondrial quality control imbalance plays an important role in COPD.This article reviews the mechanism of MQC in COPD and summarizes the progress of mitochondrial related therapies for COPD,in order to provide reference and inspiration for new strategies for COPD treatment.

关 键 词：慢性阻塞性肺疾病 线粒体动力学 线粒体质量控制 

分 类 号：R563.9[医药卫生—呼吸系统]