抗磷脂抗体在血液透析患者自体动静脉内瘘相关并发症中的研究进展  

Research progress of antiphospholipid antibody in the autologous arteriovenous fistula-related complications in hemodialysis patients

作　　者：李甜 伍杨[2] 王学良 苑书婷 何喜梅 万立平 席春生 LI Tian;WU Yang;WANG Xue-liang;YUAN Shu-ting;HE Xi-mei;WAN Li-ping;XI Chun-sheng(Department of Nephrology,the 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院肾脏病科,兰州730050 [2]甘肃中医药大学第一临床医学院,兰州730050

出　　处：《中国血液净化》2024年第12期930-933,共4页Chinese Journal of Blood Purification

基　　金：甘肃省卫生健康行业科研计划项目(GSWSKY2022-51);联勤保障部队第九四〇医院专项课题(2022yxky017);兰州市科技计划项目(2023-ZD-173)。

摘　　要：血液透析(hemodialysis,HD)是危重患者最常用的血液净化技术之一,但不可避免由于各种因素存在会导致许多并发症。其中自体动静脉内瘘(arteriovenous fistula,AVF)相关并发症是HD患者治疗失败和死亡的重要原因之一。有研究发现HD患者中普遍存在抗磷脂抗体(antiphospholipid antibody,aPL)持续阳性,似乎aPL阳性与AVF相关并发症之间存在一定关联。因此为了改善HD患者预后,减少AVF相关并发症发生,本文拟通过总结当前aPL在HD患者AVF相关并发症中的研究进展,为临床HD患者预防和治疗AVF相关并发症提供依据。Hemodialysis(HD)is one of the most commonly used blood purification techniques for critically ill patients,but it will inevitably lead to many complications due to various factors.Among them,complications related to arteriovenous fistula(AVF)are one of the important causes for treatment failure and death in HD patients.Some studies have found that persistently positive antiphospholipid antibody(aPL)is commonly present in HD patients,which may be involved in the AVF-related complications.This paper summarizes the current research progress of aPL in AVF-related complications in HD patients,in order to improve the prognosis of HD patients with AVF-related complications and to provide bases for the prevention,monitoring and treatment of the complications.

关 键 词：抗磷脂抗体 血液透析 动静脉内瘘 并发症 

分 类 号：R446.1[医药卫生—诊断学]