Stable high-peak-power fiber supercontinuum generation for adaptive femtosecond biophotonics  

作　　者：Geng Wang Jindou Shi Rishyashring R.Iyer Janet E.Sorrells Haohua Tu 

机构地区：[1]University of Illinois at Urbana-Champaign,Beckman Institute for Advanced Science and Technology,Urbana,Illinois,United States [2]University of Illinois at Urbana-Champaign,Department of Electrical and Computer Engineering,Urbana,Illinois,United States [3]University of Illinois at Urbana-Champaign,Department of Bioengineering,Urbana,Illinois,United States

出　　处：《Advanced Photonics Nexus》2024年第4期126-135,共10页先进光子学通讯（英文）

基　　金：support from the National Institutes of Health,U.S.Department of Health and Human Services(Grant No.R01 CA241618);J.E.S.and R.R.I were supported by NIBIB/NIH(Award No.T32EB019944).

摘　　要：Broad and safe access to ultrafast laser technology has been hindered by the absence of optical fiber-delivered pulses with tunable central wavelength,pulse repetition rate,and pulse width in the picosecond–femtosecond regime.To address this long-standing obstacle,we developed a reliable accessory for femtosecond ytterbium fiber chirped pulse amplifiers,termed a fiber-optic nonlinear wavelength converter(FNWC),as an adaptive optical source for the emergent field of femtosecond biophotonics.This accessory empowers the fixed-wavelength laser to produce fiber-delivered∼20 nJ pulses with central wavelength across 950 to 1150 nm,repetition rate across 1 to 10 MHz,and pulse width across 40 to 400 fs,with a long-term stability of>2000 h.As a prototypical label-free application in biology and medicine,we demonstrate the utility of FNWC in real-time intravital imaging synergistically integrated with modern machine learning and largescale fluorescence lifetime imaging microscopy.

关 键 词：femtosecond biophotonics fiber supercontinuum label-free multiphoton microscopy nonlinear optics and imaging self-supervised denoise 

分 类 号：TN2[电子电信—物理电子学]