Analysis of pulse-wave propagation characteristics in abdominal aortic sclerosis disease  

作　　者：Xuehang Sun Bensen Li Yicheng Lu Xiabo Chen Wenbo Gong Fuxing Miao 

机构地区：[1]Key Laboratory of Impact and Safety Engineering(Ministry of Education),Ningbo University,Ningbo 315211,China [2]Wanghui Workroom,Ningbo Hospital of Traditional Chinese Medicine,Ningbo 315010,China

出　　处：《Theoretical & Applied Mechanics Letters》2024年第4期237-243,共7页力学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.11872218);Zhejiang Provincial Natural Science Foundation Key Projects(Grant No.LZ23A020001);the National Natural Science Foundation of China Regional Innovation Key Project(Grant No.U21A20502);Zhejiang Province Traditional Chinese Medicine Science and Technology Foundation(Grant No.2022ZB317);the first batch of Medical and Health Brand Discipline Foundation in Ningbo(Grant No.PPXK2018-07)。

摘　　要：In this work,a bidirectional fluid-structure coupling finite element analysis model of the abdominal aorta was established,with the various vascular elastic modulus as the main parameters for atherosclerosis,taking into consideration blood's dynamic viscosity and compressibility.Pressure and velocity pulse-wave propagation were investigated through the application of a full-coupling analysis algorithm.The effect of atherosclerosis degree on the propagation characteristics of pulse waves in the bifurcated abdominal aorta was quantitatively analyzed.Arterial bifurcation can cause substantial attenuation on the peak of pressure pulse waveform and an increase in wave velocity during the cardiac cycle.The elastic modulus and bifurcation properties of the arterial wall directly affected the peak value and wave propagation velocity of the pressure pulse wave.The preliminary results of this work will be crucial in guiding the evolution of the pressure pulse wave and the initial diagnosis of atherosclerotic disease through the waveform.

关 键 词：Pulse wave ARTERIOSCLEROSIS Vascular bifurcation Fluid-solid coupled analysis model 

分 类 号：R543.12[医药卫生—心血管疾病]