自拟益气养阴通络汤加减治疗糖尿病肾病气阴两虚证的疗效及对肾血流指标的影响  

Effect of self-formulated Yiqi Yangyin Tongluo Decoction on diabetic nephropathy with Qi-Yin deficiency syndrome and its influence on renal blood flow index

作　　者：王站旗 曾凡学 WANG Zhan-qi;ZENG Fan-xue(Department of Nephrology,Liuzhou Traditional Chinese Medicine Hospital,Liuzhou 545001,Guangxi,CHINA)

机构地区：[1]柳州市中医医院肾内科,广西柳州545001

出　　处：《海南医学》2024年第23期3370-3373,共4页Hainan Medical Journal

摘　　要：目的探讨自拟益气养阴通络汤加减治疗糖尿病肾病气阴两虚证的疗效及对肾血流指标的影响。方法回顾性分析2020年6月至2023年4月柳州市中医医院收治的83例糖尿病肾病患者的临床资料,按照治疗方式不同分为观察组43例和对照组40例。对照组患者采用常规治疗,观察组患者在对照组治疗基础上联合自拟益气养阴通络汤加减治疗,均持续治疗3个月。比较两组患者治疗3个月后的临床疗效,治疗前、治疗3个月后空腹血糖(FBG)、糖化血红蛋白(HbA1c)、尿素氮(BUN)、血肌酐(Scr)、肾小球滤过率(eGFR)、肾段动脉的最大血流速度(V_(max))、最小血流速度(V_(min))、阻力指数(RI)的变化,并比较两组患者治疗期间的不良反应发生率。结果治疗后,观察组患者的临床治疗总有效率为93.02%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,观察组患者的FBG、HbA1c、BUN、Scr分别为(7.32±1.04)mmol/L、(6.02±0.61)%、(5.31±1.02)mmol/L、(79.15±11.47)μmol/L,明显低于对照组的(7.95±1.01)mmol/L、(6.38±0.75)%、(5.95±1.33)mmol/L、(90.01±10.25)μmol/L,eGFR为(85.27±6.38)mL/(min·1.73 m^(2)),明显高于对照组的(79.30±6.29)mL/(min·1.73 m^(2)),差异均有统计学意义(P<0.05);治疗后,观察组患者的V_(max)、V_(min)分别为(52.53±3.64)cm/s、(21.12±2.53)cm/s,明显高于对照组的(50.18±3.65)cm/s、(19.58±2.05)cm/s,RI为0.60±0.05,明显低于对照组的0.64±0.06,差异均有统计学意义(P<0.05);观察组和对照组患者治疗期间的不良反应总发生率分别为13.95%、10.00%,差异无统计学意义(P>0.05)。结论自拟益气养阴通络汤加减治疗糖尿病肾病气阴两虚证可有效改善患者的肾血流指标,疗效较好且安全性较高。Objective To study the effect of self-formulated Yiqi Yangyin Tongluo Decoction on diabetic nephropathy with Qi-Yin deficiency syndrome and its influence on renal blood flow index.Methods The clinical data of 83 patients with diabetic nephropathy admitted to Liuzhou Traditional Chinese Medicine Hospital from June 2020 to April 2023 were retrospectively analyzed.The patients were divided into an observation group(n=43)and a control group(n=40)according to different treatment methods.Patients in the control group received conventional treatment,and those in the observation group were treated with self-formulated Yiqi Yangyin Tongluo Decoction on the basis of the treatment in the control group,all for 3 months.The clinical efficacy after 3 months of treatment were compared between the two groups,as well as the changes of fasting blood glucose(FBG),glycated hemoglobin(HbA1c),urea nitrogen(BUN),serum creatinine(Scr),estimated glomerular filtration rate(eGFR),maximum blood flow velocity(V_(max))and minimum blood flow velocity(V_(min))of renal artery,resistance index(RI)before treatment and after 3 months of treatment.The incidence of adverse reactions during treatment was compared between the two groups.Results After treatment,the total effective rate of clinical treatment in the observation group was 93.02%,which was significantly higher than 75.00%of the control group(P<0.05).After treatment,the FBG,HbA1c,BUN,and Scr in the observation group were(7.32±1.04)mmol/L,(6.02±0.61)%,(5.31±1.02)mmol/L,and(79.15±11.47)μmol/L,which were significantly lower than(7.95±1.01)mmol/L,(6.38±0.75)%,(5.95±1.33)mmol/L,(90.01±10.25)μmol/L in the control group;the eGFR were(85.27±6.38)mL/(min·1.73 m^(2)),which were significantly higher than(79.30±6.29)mL/(min·1.73 m^(2))of the control group;the differences were statistically significant(P<0.05).After treatment,the V_(max) and V_(min) in the observation group were(52.53±3.64)cm/s and(21.12±2.53)cm/s,which were significantly higher than(50.18±3.65)cm/s and(19.58±2.05)cm/s

关 键 词：糖尿病肾病 气阴两虚证 肾功能 肾血流 疗效 不良反应 

分 类 号：R587.2[医药卫生—内分泌]