补肾养胎方联合地屈孕酮治疗肾虚型早期先兆流产临床研究  

Clinical Study on Bushen Yangtai Prescription and Dydrogesterone for Early Threat⁃ened Abortion of Kidney Deficiency Type

作　　者：吕芸 曹文丽 施晓 LYU Yun;CAO Wenli;SHI Xiao(Department of Traditional Chinese Medicine,Zhoushan Women and Children's Hospital,Zhoushan Zhejiang 316000,China;Reproductive Center,Zhoushan Women and Children's Hospital,Zhoushan Zhejiang 316000,China;Obstetrics and Gynecology Department,Zhoushan Women and Children's Hospital,Zhoushan Zhejiang 316000,China)

机构地区：[1]舟山市妇女儿童医院中医科,浙江舟山316000 [2]舟山市妇女儿童医院生殖中心,浙江舟山316000 [3]舟山市妇女儿童医院妇产科,浙江舟山316000

出　　处：《新中医》2024年第23期69-72,共4页New Chinese Medicine

摘　　要：目的:观察补肾养胎方联合地屈孕酮治疗肾虚型早期先兆流产的临床疗效及对妊娠结局的影响。方法:采用随机数字表法将92例肾虚型早期先兆流产患者分为对照组与治疗组各46例。对照组给予地屈孕酮片口服治疗,治疗组给予补肾养胎方联合地屈孕酮治疗。比较2组治疗前后中医证候评分、妊娠激素水平及妊娠结局,并评估2组临床疗效与不良反应发生情况。结果:治疗组总有效率97.83%,高于对照组82.61%(P<0.05)。治疗后,2组中医证候评分均较治疗前降低(P<0.05),雌二醇(E_(2))、人绒毛膜促性腺激素(HCG)、孕酮(P)水平升高(P<0.05),治疗组治疗后E_(2)、HCG、P水平均高于对照组(P<0.05),中医证候评分低于对照组(P<0.05)。治疗组足月妊娠率89.13%,高于对照组71.74%(P<0.05)。治疗组流产率、不良反应发生率分别为6.52%、4.35%,低于对照组21.74%、17.39%(P<0.05)。2组早产率比较,差异无统计学意义(P>0.05)。结论:补肾养胎方联合地屈孕酮治疗肾虚型早期先兆流产疗效确切,能够调节患者妊娠激素,提高保胎效果,改善妊娠结局,安全性高。Objective:To observe the effect of Bushen Yangtai Prescription and Dydrogesterone on early threatened abortion of kidney deficiency type and its effect on pregnancy outcome.Methods:A total of 92 cases with early threatened abortion of kidney deficiency type were randomly divided into control and treatment groups,with 46 patients in each group.The control group was treated with oral administration of Dydrogesterone Tablets,and the treatment group was treated with a combination of Bushen Yangtai Prescription and Dydrogesterone.Compared the traditional Chinese medicine(TCM)syndrome scores,pregnancy hormone levels,and pregnancy outcomes between the two groups before and after treatment,and evaluated the clinical effects and incidence of adverse reactions between the two groups.Results:The total effective rate was 97.83%in treatment group,which was higher than that of 82.61%in control group(P<0.05).After treatment,the TCM syndrome scores in both groups were decreased when compared with those before treatment(P<0.05),and the levels of estradiol(E_(2)),human chorionic gonadotropin(HCG),and progesterone(P)were increased(P<0.05).After treatment,the levels of E_(2),HCG,and P in treatment group were higher than those in control group(P<0.05),and the TCM syndrome score was lower than that in the control group(P<0.05).The full-term pregnancy rate in the treatment group was 89.13%,which was higher than that of 71.74%in control group(P<0.05).The abortion rate and incidence of adverse reactions in the treatment group were 6.52%and 4.35%,respectively,which were lower than those in control group of 21.74%and 17.39%(P<0.05).The premature delivery rates between the two groups was no significant(P>0.05).Conclusion:The combination of Bushen Yangtai Prescription and Dydrogesterone has a definite therapeutic effect on early threatened abortion of kidney deficienet type.It can regulate the levels of pregnancy hormones,improve the effectiveness of fetal protection,and improve pregnancy outcomes,with high safety.

关 键 词：早期先兆流产 肾虚证 补肾养胎方 地屈孕酮 妊娠激素 

分 类 号：R271.1[医药卫生—中医妇科学]